Department of Radiotherapy, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Department of Severe Care Unit, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
J Obstet Gynaecol Res. 2022 Apr;48(4):1011-1018. doi: 10.1111/jog.15163. Epub 2022 Feb 22.
Integrin alpha 7 (ITGA7) regulates cancer stemness and metastasis in several malignancies, while its role in cervical cancer is obscure. Therefore, the current study aimed to investigate the correlation among ITGA7, cluster of differentiation 133 (CD133), and aldehyde dehydrogenase isoform 1 (ALDH1), as well as their relation to tumor features and survival in cervical cancer patients.
A total of 133 surgical cervical cancer patients were enrolled. Tumor ITGA7, CD133, and ALDH1 expressions were determined by immunohistochemistry (IHC). Furthermore, the clinicopathological features, disease-free survival (DFS), and overall survival (OS) were collected.
ITGA7 expression positively related to CD133 expression (p = 0.040) and ALDH1 expression (p < 0.001). Besides, ITGA7 (p = 0.001), CD133 (p = 0.016), and ALDH1 (p = 0.009) high expressions linked with poor tumor differentiation; meanwhile, ITGA7 (p = 0.010) and ALDH1 (p = 0.004) high expressions correlated with more prevalence of lymph node metastasis. However, ITGA7, CD133, or ALDH1 expression was not associated with other clinicopathological features. Inspiringly, it was worth noting that ITGA7 (p = 0.009), CD133 (p = 0.041), and ALDH1 (p = 0.035) high expressions predicted unfavorable DFS; meanwhile, both ITGA7 (p = 0.021) and ALDH1 (p = 0.023) high expressions but not CD133 expression (p = 0.169) forecasted exasperated OS.
ITGA7, CD133, ALDH1 are inter-correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer.
整合素 α7（ITGA7）在几种恶性肿瘤中调节癌症干细胞特性和转移，但其在宫颈癌中的作用尚不清楚。因此，本研究旨在探讨 ITGA7、CD133 和醛脱氢酶同工酶 1（ALDH1）之间的相关性，以及它们与宫颈癌患者肿瘤特征和生存的关系。
共纳入 133 例手术治疗的宫颈癌患者。采用免疫组织化学法（IHC）检测肿瘤 ITGA7、CD133 和 ALDH1 的表达。此外，还收集了临床病理特征、无病生存（DFS）和总生存（OS）。
ITGA7 表达与 CD133 表达呈正相关（p=0.040）和 ALDH1 表达呈正相关（p<0.001）。此外，ITGA7（p=0.001）、CD133（p=0.016）和 ALDH1（p=0.009）高表达与肿瘤分化差有关；同时，ITGA7（p=0.010）和 ALDH1（p=0.004）高表达与淋巴结转移更为普遍有关。然而，ITGA7、CD133 或 ALDH1 的表达与其他临床病理特征无关。令人鼓舞的是，值得注意的是，ITGA7（p=0.009）、CD133（p=0.041）和 ALDH1（p=0.035）高表达预测DFS 不良；同时，ITGA7（p=0.021）和 ALDH1（p=0.023）高表达而非 CD133 表达（p=0.169）预测 OS 恶化。
ITGA7、CD133、ALDH1 相互关联，与手术治疗的宫颈癌患者分化差、淋巴结转移以及生存不良有关。
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