Department of Chemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
Angew Chem Int Ed Engl. 2022 Apr 25;61(18):e202201700. doi: 10.1002/anie.202201700. Epub 2022 Mar 4.
A strategy for the generation of heterotrimetallic double cavity (DC) cages [Pd Pt L ] (DC1: n=1, m=2; and DC2: n=2, m=1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and Pd ions. H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2 were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single-crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities, was found to interact with two different guests, 5-FU and cisplatin, selectively.
报道了一种异三金属双腔（DC）笼[PdPtL]（DC1：n=1，m=2；和 DC2：n=2，m=1）的生成策略。通过将惰性铂（II）四吡咯醛配合物与适当取代的吡啶胺和 Pd 离子组合，生成了 DC 笼。H 和 DOSY 核磁共振波谱（NMR）和电喷雾电离质谱（ESIMS）数据与 DC 结构的形成一致。DC1 和 DC2 被证明可以与几种不同的客体分子相互作用。通过单晶 X 射线晶体学确定了具有两个相同腔室、结合两个 2,6-二氨基蒽醌（DAQ）客体分子的 DC1 的结构。此外，DC1 被证明以统计（非协同）方式结合两个 5-氟尿嘧啶（5-FU）分子。相比之下，具有两个不同笼腔的 DC2 被发现与两个不同的客体分子，5-FU 和顺铂，选择性地相互作用。
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