Sandelin Atte, Hälli Outi, Härtel Heidi, Herva Tuomas, Kaartinen Liisa, Tuunainen Erja, Rautala Helena, Soveri Timo, Simojoki Heli
Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, FI-04920 Saarentaus, Finland.
HKScan Finland Ltd., Lemminkäisenkatu 48, FI-20520 Turku, Finland.
Antibiotics (Basel). 2022 Feb 18;11(2):270. doi: 10.3390/antibiotics11020270.
Antimicrobial resistance has been recognized as one of the top health threats to human society. Abundant use of antibiotics in both humans and animals has led to ever-increasing antibiotic resistance in bacteria. In food production, decreasing morbidity in beef herds would be an effective way to reduce the use of antibiotics. The objective of this retrospective observational study was to determine overall morbidity on calf rearing farms and to identify associated risk factors. Data were collected by questionnaire, meat companies' databases and the national cattle register for 28,228 calves transported to 87 calf rearing farms. All medications given to these calves were retrospectively followed for 180 days from calf arrival to the farm. In total, 34,532 parenteral antibiotic medications were administered to the 28,228 study calves (122.3%), and 17,180 calves (60.9%) were medicated with antibiotics at least once during the follow-up. Higher numbers of calves transported to the same farm and larger age variation in calves in the same arrival batch were both associated with increased morbidity. In contrast, higher arrival age of individual calves was associated with decreased morbidity. Our study identifies several factors to consider in decreasing morbidity and antibiotic usage on calf rearing farms.
抗菌药物耐药性已被公认为对人类社会的主要健康威胁之一。人类和动物大量使用抗生素导致细菌中的抗生素耐药性不断增加。在食品生产中，降低肉牛群的发病率将是减少抗生素使用的有效方法。这项回顾性观察研究的目的是确定犊牛饲养场的总体发病率，并识别相关的风险因素。通过问卷调查、肉类公司数据库和国家牲畜登记册收集了运往87个犊牛饲养场的28228头犊牛的数据。从犊牛抵达农场开始，对这些犊牛使用的所有药物进行了为期180天的回顾性跟踪。总共对28228头研究犊牛使用了34532次注射用抗生素药物（122.3%），在随访期间，17180头犊牛（60.9%）至少接受过一次抗生素治疗。运往同一农场的犊牛数量较多以及同一批次抵达的犊牛年龄差异较大均与发病率增加有关。相比之下，个体犊牛的抵达年龄较大与发病率降低有关。我们的研究确定了在降低犊牛饲养场发病率和抗生素使用方面需要考虑的几个因素。
