艾拉莫德治疗原发性干燥综合征合并自身免疫性溶血性贫血：一例报告
Iguratimod in treatment of primary Sjögren's syndrome concomitant with autoimmune hemolytic anemia: A case report.
作者信息
Zhang Juan, Wang Xin, Tian Jing-Jing, Zhu Rong, Duo Rui-Xue, Huang Yi-Chen, Shen Hai-Li
机构信息
Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
Second Clinical Medical College, Lanzhou University, Lanzhou 730030, Gansu Province, China.
出版信息
World J Clin Cases. 2022 Feb 6;10(4):1286-1290. doi: 10.12998/wjcc.v10.i4.1286.
BACKGROUND
Primary Sjögren's syndrome (pSS) concomitant with autoimmune hemolytic anemia (AIHA) but without eye and mouth dryness is exceedingly rare. Iguratimod (IGU) has been widely used in the treatment of pSS. However, there are few reports about the application of IGU in pSS concomitant with AIHA.
CASE SUMMARY
Here, we present the case of a patient with pSS concomitant with AIHA but without eye and mouth dryness. The patient was initially diagnosed with hyperplastic anemia and AIHA while pSS was missed, and was finally diagnosed with pSS concomitant with AIHA. The patient was treated with IGU along with prednisone and hydroxychloroquine, and her hemoglobin, reticulocytes and IgG returned to normal levels.
CONCLUSION
IGU was effective for and well tolerated by our patient with pSS concomitant with AIHA, and may be a promising therapy for the treatment of this disease.
背景
原发性干燥综合征（pSS）合并自身免疫性溶血性贫血（AIHA）但无眼干和口干极为罕见。艾拉莫德（IGU）已广泛用于治疗pSS。然而，关于IGU在合并AIHA的pSS中的应用报道很少。
病例摘要
在此，我们报告一例pSS合并AIHA但无眼干和口干的患者。该患者最初被诊断为增生性贫血和AIHA，而漏诊了pSS，最终被诊断为pSS合并AIHA。患者接受IGU联合泼尼松和羟氯喹治疗，其血红蛋白、网织红细胞和IgG恢复至正常水平。
结论
IGU对我们这位合并AIHA的pSS患者有效且耐受性良好，可能是治疗该疾病的一种有前景的疗法。
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