Department of Obstetrics and Gynecology, University of Gezira, Sudan. P.O. Box 20, Wad Medani 21111, Sudan.
College of Medicine, King Khalid University, Abha 61421, Saudi Arabia.
Nutrients. 2022 Feb 20;14(4):891. doi: 10.3390/nu14040891.
There are few published studies on the association between vitamin D concentrations and preterm birth (PB) in sub-Saharan Africa. The current study aimed to assess the association between 25-hydroxyvitamin D (25[OH)] D) levels and PB. A matched case-control study (60 women in each arm) was conducted in Medani maternity hospital in central Sudan. The cases were women with spontaneous PB, and healthy women with term deliveries were the controls. The clinical/medical and obstetric history was gathered using a questionnaire. The enzyme-linked immunosorbent assay was used to measure the serum 25(OH)D levels. Women with PB had significantly lower median (interquartile range) 25(OH)D concentrations compared with the controls (18.4 (7.3) ng/mL vs. 20.2 (16.5) ng/mL, = 0.001). Forty-two (70.0%) women with PB and 29 (48.3%) women in the control group had vitamin D deficiency (25(OH)D level ≤ 20 ng/mL). The results of the multivariable logistic regression showed that the 25(OH)D concentrations were negatively associated with PB (adjusted odds ratio (aOR) = 0.92, 95% confidence interval (CI) = 0.87-0.97). Vitamin D-deficient pregnant women were at a higher risk of PB (aOR = 2.69, 95% CI = 1.17-6.23). Low 25(OH)D concentrations were found at the time the variable was determined in women with spontaneous PB and were an independent risk factor for PB.
在撒哈拉以南非洲，关于维生素 D 浓度与早产（PB）之间的关联，发表的研究很少。本研究旨在评估 25-羟维生素 D（25（OH）D）水平与 PB 之间的关系。在苏丹中部的 Medani 妇产医院进行了一项匹配的病例对照研究（每组 60 名妇女）。病例为自发性 PB 妇女，健康足月分娩妇女为对照组。使用问卷收集临床/医学和产科史。酶联免疫吸附试验用于测量血清 25（OH）D 水平。与对照组相比，PB 妇女的 25（OH）D 浓度中位数（四分位距）明显较低（18.4（7.3）ng/mL 比 20.2（16.5）ng/mL， = 0.001）。42 名（70.0%）PB 妇女和对照组中 29 名（48.3%）妇女患有维生素 D 缺乏症（25（OH）D 水平≤20ng/mL）。多变量逻辑回归的结果表明，25（OH）D 浓度与 PB 呈负相关（调整优势比（aOR）=0.92，95%置信区间（CI）=0.87-0.97）。维生素 D 缺乏的孕妇发生 PB 的风险更高（aOR=2.69，95%CI=1.17-6.23）。在自发性 PB 妇女确定该变量时发现 25（OH）D 浓度较低，是 PB 的独立危险因素。
