肌少症对结直肠癌腹腔镜手术的外科及肿瘤学结局的影响。
Impact of sarcopenia on surgical and oncologic outcomes of laparoscopic surgery for colorectal cancer.
作者信息
Takenami Tsutomu, Tsujinaka Shingo, Miyakura Yasuyuki, Kakizawa Nao, Maemoto Ryo, Machida Erika, Hatsuzawa Yuuri, Takahashi Rei, Kimura Yasuaki, Tamaki Sawako, Ishikawa Hideki, Rikiyama Toshiki
机构信息
Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
出版信息
Asian J Surg. 2022 Dec;45(12):2686-2690. doi: 10.1016/j.asjsur.2021.12.075. Epub 2022 Feb 25.
BACKGROUND
The study aimed to evaluate the impact of sarcopenia on short- and long-term outcomes for laparoscopic colorectal cancer surgery.
METHODS
Study participants were 209 patients who underwent laparoscopic surgery for any stage of colorectal cancer between 2016 and 2017. Skeletal muscle indices were calculated with preoperative computed tomography. Patients were divided into sarcopenic and non-sarcopenic groups based on index cut-off values and variables were compared.
RESULTS
The prevalence of sarcopenia was 41.1%. Sarcopenic patients experienced shorter operative times and a lower incidence of surgical site infections; however, the incidence of severe postoperative complications and readmission were increased for this group. Although the 3-year disease-free survival rate was not statistically different between groups, sarcopenic patients had a significantly worse 3-year overall survival rate compared with than the non-sarcopenic group.
CONCLUSION
Sarcopenia has both favorable and unfavorable effects on patients who underwent laparoscopic colorectal cancer surgery.
背景
本研究旨在评估肌肉减少症对腹腔镜结直肠癌手术短期和长期预后的影响。
方法
研究参与者为209例在2016年至2017年间接受任何阶段结直肠癌腹腔镜手术的患者。术前通过计算机断层扫描计算骨骼肌指数。根据指数临界值将患者分为肌肉减少症组和非肌肉减少症组，并比较变量。
结果
肌肉减少症的患病率为41.1%。肌肉减少症患者的手术时间较短，手术部位感染发生率较低；然而，该组严重术后并发症和再入院的发生率有所增加。尽管两组之间的3年无病生存率无统计学差异，但与非肌肉减少症组相比，肌肉减少症患者的3年总生存率明显更差。
结论
肌肉减少症对接受腹腔镜结直肠癌手术的患者既有有利影响，也有不利影响。
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