围产期普通狨猴巨幼细胞贫血的诊断与治疗：一例报告
Diagnosis and treatment of macrocytic anemia in a perinatal common marmoset: a case report.
作者信息
Kim Jong-Min, Kwak Jina, Lim Hyun-Jin, Kim Joo-Il, Kang Byeong-Cheol
机构信息
Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea.
Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea.
出版信息
Lab Anim Res. 2022 Feb 28;38(1):6. doi: 10.1186/s42826-022-00115-6.
BACKGROUND
The common marmoset is widely used in current biomedical research for various research fields. We observed macrocytic anemia in a perinatal common marmoset with gradual weight loss and diarrhea. The objective of this case report is to describe the diagnosis and treatment of macrocytic anemia in a perinatal common marmoset.
CASE PRESENTATION
A 7-year-old female common marmoset showed clinical signs of gradual weight loss and intermittent diarrhea beginning 3 months after giving birth. Macrocytic anemia was diagnosed due to a decreased red blood cell (RBC) count, low hemoglobin level, and increased mean corpuscular volume (MCV). Multivitamins containing cobalamin and folate were administered for 7 days, and the patient's RBC count recovered to near the normal range with this treatment.
CONCLUSIONS
Macrocytic anemia can be diagnosed by evaluating the MCV on a complete blood count (CBC) and cobalamin or folate levels and be treated by supplementation with cobalamin and folate. Such supplements may be needed during pregnancy and lactation in female common marmosets and/or in animals with chronic diarrhea.
背景
普通狨猴目前广泛应用于多个研究领域的生物医学研究中。我们在一只围产期普通狨猴身上观察到巨细胞性贫血，伴有体重逐渐减轻和腹泻。本病例报告的目的是描述一只围产期普通狨猴巨细胞性贫血的诊断和治疗情况。
病例介绍
一只7岁雌性普通狨猴在产后3个月开始出现体重逐渐减轻和间歇性腹泻的临床症状。由于红细胞计数减少、血红蛋白水平降低和平均红细胞体积增加，诊断为巨细胞性贫血。给予含钴胺素和叶酸的多种维生素治疗7天，通过该治疗，患者的红细胞计数恢复到接近正常范围。
结论
可通过全血细胞计数（CBC）评估平均红细胞体积以及钴胺素或叶酸水平来诊断巨细胞性贫血，并通过补充钴胺素和叶酸进行治疗。在雌性普通狨猴怀孕和哺乳期间以及/或患有慢性腹泻的动物中可能需要此类补充剂。
Zotero 插件