Loos Jeanette N, D'Acierno Francesco, Vijay Mody Urmi, MacLachlan Mark J
University of British Columbia, Department of Chemistry, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada.
Department of Physics and Astronomy, The University of British Columbia, 6224 Agricultural Rd., Vancouver, British Columbia, V6T 1Z1, Canada.
Chempluschem. 2022 Mar 1;87(4):e202200026. doi: 10.1002/cplu.202200026.
Multicomponent low molecular weight gelators (LMWGs) may self-assemble by co-assembly (CA), social self-sorting (SSS), or narcissistic self-sorting (NSS). Understanding the nuances of the self-assembly processes is important to predict the behavior of multicomponent organogels. Here, we investigate the effect of molecular structure on self-assembly in a series of amino-acid based bicomponent LMWGs that differ in headgroup and alkyl chain length. Packing preference of the organogels was determined using differential scanning calorimetry, nuclear magnetic resonance spectroscopy and small angle X-ray scattering. From 66 bicomponent samples we found 50 CA, 14 SSS and 2 NSS. Furthermore, we performed statistical analysis to investigate the role of hydrophobicity and chain length on the overall pathway of self-assembly for these systems. We found the hydrophobicity of the headgroup strongly affected the assembly preference of the organogel, but alkyl chain length only played a small role.
多组分低分子量凝胶剂（LMWGs）可通过共组装（CA）、社交自分类（SSS）或自恋自分类（NSS）进行自组装。了解自组装过程的细微差别对于预测多组分有机凝胶的行为很重要。在此，我们研究了分子结构对一系列基于氨基酸的双组分LMWGs自组装的影响，这些凝胶剂在头基和烷基链长度上有所不同。使用差示扫描量热法、核磁共振光谱和小角X射线散射确定有机凝胶的堆积偏好。从66个双组分样品中，我们发现了50个CA、14个SSS和2个NSS。此外，我们进行了统计分析，以研究疏水性和链长对这些系统自组装总体途径的作用。我们发现头基的疏水性强烈影响有机凝胶的组装偏好，但烷基链长度只起很小的作用。
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