Wallberg-Henriksson H
Acta Physiol Scand. 1986 May;127(1):39-43. doi: 10.1111/j.1748-1716.1986.tb07873.x.
The present study was undertaken to test the hypothesis that a muscle's habitual level of contractile activity might act as a long-term regulator of glucose transport capacity. Rats were rendered severely diabetic by injection of streptozotocin, 125 mg kg-1 body wt. Three days after the injection, insulin-stimulated and contraction-induced 3-methylglucose transport in the in vitro epitrochlearis muscle preparation was reduced to 25% and 52% of control capacity, respectively (P less than 0.001). However, when repeated 1-h swimming sessions (twice a day) were introduced during the 3 days of insulin deficiency, the reduction in contraction-induced glucose transport capacity was completely abolished. This indicates that the habitual level of contractile activity of a muscle regulates its capacity for exercise-stimulated glucose transport. Furthermore, one exercise session and a maximal insulin stimulus had an additive effect on 3-methylglucose transport, suggesting that there are two pools of intracellular glucose transporters or two mechanisms for mobilizing the same pool.
肌肉的习惯性收缩活动水平可能作为葡萄糖转运能力的长期调节因子。通过注射链脲佐菌素（125 mg/kg体重）使大鼠患严重糖尿病。注射后三天，体外肱三头肌制备物中胰岛素刺激和收缩诱导的3-甲基葡萄糖转运分别降至对照能力的25%和52%（P<0.001）。然而，在胰岛素缺乏的三天期间，当引入重复的1小时游泳训练（每天两次）时，收缩诱导的葡萄糖转运能力的降低被完全消除。这表明肌肉的习惯性收缩活动水平调节其运动刺激的葡萄糖转运能力。此外，一次运动训练和最大胰岛素刺激对3-甲基葡萄糖转运有相加作用，提示存在两池细胞内葡萄糖转运体或两种动员同一池转运体的机制。
