预防性髋关节异位骨化放疗：叙事性迷你综述。
Prophylactic Radiotherapy of Hip Heterotopic Ossification: A Narrative Mini Review.
机构信息
Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, Bologna, Italy;
U.O. Ortopedia e Traumatologia, AUSL Imola, Imola, Italy.
出版信息
In Vivo. 2022 Mar-Apr;36(2):533-542. doi: 10.21873/invivo.12735.
Evidence on prophylactic radiotherapy (RT) in hip heterotopic ossification (HO) is sparse and conflicting. The aim of this literature review was to collect and summarize the available data on RT efficacy in preventing hip HO. The results of this review show that RT is effective in the prevention of hip HO, albeit with large variability across series. Effective prophylactic RT requires optimal treatment fields and time intervals with surgery. On the contrary, there is no clear evidence on the optimal timing (post-operative versus pre-operative RT). Comparisons between prophylactic RT and use of non-steroidal anti-inflammatory drugs showed conflicting results, although most were in favor of RT. In conclusion, RT is an established prophylactic treatment for hip HO. However, optimal dose, technique and timing remain unclear, as does the usefulness of combining RT with drugs.
关于预防性放射治疗（RT）在髋关节异位骨化（HO）中的作用的证据有限且相互矛盾。本文献综述的目的是收集和总结现有关于 RT 预防髋关节 HO 疗效的数据。本综述的结果表明，RT 在预防髋关节 HO 方面是有效的，但各系列之间的差异很大。有效的预防性 RT 需要与手术相匹配的最佳治疗野和时间间隔。相反，关于最佳时机（术后 RT 与术前 RT）尚无明确证据。预防性 RT 与非甾体类抗炎药（NSAIDs）使用的比较结果相互矛盾，尽管大多数结果倾向于 RT。总之，RT 是一种已确立的髋关节 HO 预防性治疗方法。然而，最佳剂量、技术和时机仍不清楚，RT 与药物联合使用的效果也不清楚。
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