State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Pennsylvania College of Optometry at Salus University, Elkins Park, Pennsylvania, USA.
Ophthalmic Physiol Opt. 2022 Jul;42(4):913-920. doi: 10.1111/opo.12972. Epub 2022 Mar 4.
To evaluate the reliability of the step vergence method in measuring fusional vergence in subjects with intermittent exotropia.
Thirty-two Chinese participants aged 7-20 years with intermittent exotropia (excluding the convergence insufficiency type) were enrolled in this prospective study. At the eligibility screening, visual acuity, cover test and the Office Control Score were performed. For eligible participants at study visit 1, negative and positive fusional vergence at distance and near, eye dominance and the fusion maintenance test were performed. All eligible participants returned for study visit 2 on the same day (2-4 h later), and the testing was repeated. The primary outcome measures were the intra-class correlation coefficient, coefficient of repeatability and smallest detectable change in the break and recovery points of negative and positive fusional vergence between the two study visits.
The intra-class correlation coefficient for different vergence parameters ranged from 0.64 to 0.87. The coefficient of repeatability and the smallest detectable change for the distance positive fusional vergence break point were ±20.5 and 13.1 ∆, respectively. There was no significant difference in any vergence parameter between the first and second visits. The coefficient of repeatability and the smallest detectable change in all distance vergence parameters were high when compared to the mean value. The association between distance vergence parameters and the Office Control Score was significant only when including subjects who failed to fuse at the beginning of the test.
The data demonstrate that measurement of fusional vergence with a prism bar has low repeatability in subjects with intermittent exotropia. In these individuals, convergence ability at distance is compromised, whereas other vergence parameters are not adversely affected. While the step vergence method is a valuable test in daily practice, caution is warranted when using it in clinical research.
评估阶梯聚散法测量间歇性外斜视患者融合聚散的可靠性。
本前瞻性研究纳入了 32 名年龄在 7-20 岁之间的中国间歇性外斜视(不包括集合不足型)患者。在资格筛选时,进行了视力、遮盖试验和办公室控制评分。对于第 1 次研究访问时符合条件的参与者,进行了远距和近距负性和正性融合聚散、主导眼和融合维持试验。所有符合条件的参与者于同日(2-4 小时后)返回第 2 次研究访问,并重复进行测试。主要观察指标是两次研究访问之间负性和正性融合聚散的破裂和恢复点的组内相关系数、重复性系数和最小可检测变化。
不同聚散参数的组内相关系数范围为 0.64 至 0.87。远距正性融合聚散破裂点的重复性系数和最小可检测变化分别为±20.5 和 13.1 ∆。第一次和第二次访问之间,各聚散参数均无显著差异。与平均值相比,所有远距聚散参数的重复性系数和最小可检测变化均较高。仅当包括在试验开始时无法融合的受试者时,远距聚散参数与办公室控制评分之间的相关性才具有统计学意义。
数据表明,棱镜棒法测量间歇性外斜视患者的融合聚散重复性低。在这些患者中,远距集合能力受损,而其他聚散参数未受不利影响。虽然阶梯聚散法在日常实践中是一种有价值的测试方法,但在临床研究中使用时需要谨慎。