突尼斯肿瘤血液病病房医源性感染的流行情况。

Prevalence of healthcare-associated infections at a Tunisian onco-hematology ward.

出版信息

Tunis Med. 2021;99(5):552-559.

Abstract

INTRODUCTION

Healthcare-associated infections (HAIs) are with high rates of mortality and an additional cost, in onco-hematology patients.

AIM

To assess the prevalence trends of HAIs in the onco-hematology ward of the Tunisian National Bone Marrow Transplant Center (NBMTC), and to determine the principal associated risk factors.

METHODS

Six repeated point prevalence surveys were conducted, from May 2018 to March 2019, using a two months interval. All patients hospitalized in the day of the survey were included. Risk factors of HAIs were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). They were assessed using a logistic regression model.

RESULTS

Nineteen patients out of a total of 74 patients have been diagnosed with 19 HAIs, representing a prevalence of 25.7%. No significant downward or upward trend of prevalence was revealed over time (p=0.3). The most common HAI was respiratory tract infection (57.9%) with a prevalence of 14.9%. Multiple logistic regression analysis revealed that HAI was significantly associated with neutropenia (Adjusted OR: 14; 95% CI: 1.5-127; p=0.01) and duration of central venous catheter (Adjusted OR: 1.1; 95% CI: 1-1.2; p=0.005).

CONCLUSION

High prevalence of HAIs in our center with a high rate of mortality, requiring identifying potential problems in infection control practices.

摘要

简介

医疗保健相关感染（HAIs）在肿瘤血液病患者中具有高死亡率和额外成本。

目的

评估突尼斯国家骨髓移植中心（NBMTC）肿瘤血液病病房中 HAI 的流行趋势，并确定主要相关危险因素。

方法

从 2018 年 5 月至 2019 年 3 月，每隔两个月进行了六次重复的点患病率调查。所有在调查当天住院的患者均被纳入。HAI 的危险因素表示为比值比（OR）及其 95%置信区间（CI）。使用逻辑回归模型进行评估。

结果

在总共 74 名患者中，有 19 名患者被诊断出患有 19 种 HAI，患病率为 25.7%。随着时间的推移，患病率没有明显的下降或上升趋势（p=0.3）。最常见的 HAI 是呼吸道感染（57.9%），患病率为 14.9%。多变量逻辑回归分析表明，HAI 与中性粒细胞减少症显著相关（调整后的 OR：14；95%CI：1.5-127；p=0.01）和中央静脉导管留置时间（调整后的 OR：1.1；95%CI：1-1.2；p=0.005）。