Post Graduate Institute of Medical Education & Research, Chandigarh, India.
Post Graduate Institute of Medical Education & Research, Chandigarh, India.
J Affect Disord. 2022 May 15;305:233-239. doi: 10.1016/j.jad.2022.02.070. Epub 2022 Mar 3.
Most of the available data on the prevalence and impact of psychotic symptoms on the course of bipolar disorder (BD) is from Western countries. We aimed to study the prevalence of at least one psychotic episode in the lifetime in patients with BD and its association with the long-term course and outcome.
773 patients recruited as part of the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study) were divided into 2 groups, based on the presence or absence of at least one psychotic episode in the lifetime.
326 (42.2%) patients had at least one psychotic episode in their lifetime. At least one psychotic episode in the lifetime was associated with overall more severe illness in terms of lower age of onset, a higher number of episodes in the first 5 years of illness; higher rates of BD-II, a higher rate of lifetime history of at least 1 suicide attempt, lifetime history of hospitalization, history of receiving Electroconvulsive Therapy, and a higher prescription rates of antipsychotics. However, presence of psychotics symptoms was associated with better cognitive functioning.
Our findings suggest that the presence of psychotic symptoms during episodes in patients with BD is associated with poorer course of BD.
大多数关于双相情感障碍（BD）病程中精神病症状的患病率和影响的可用数据来自西方国家。我们旨在研究 BD 患者一生中至少出现一次精神病发作的患病率及其与长期病程和结局的关系。
从印度招募的作为双相情感障碍病程和结局研究（BiD-CoIN 研究）一部分的 773 名患者，根据一生中是否至少出现过一次精神病发作，分为两组。
326 名（42.2%）患者一生中至少出现过一次精神病发作。一生中至少出现一次精神病发作与整体更严重的疾病相关，表现为发病年龄更早，发病的前 5 年内发作次数更多；BD-II 的发生率更高，一生中至少有 1 次自杀企图、住院治疗、电休克治疗和使用抗精神病药物的历史更高。然而，精神病症状的存在与更好的认知功能相关。
我们的发现表明，BD 患者发作期间出现精神病症状与 BD 病程较差有关。
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