心肌梗死患者的嗜酸粒细胞趋化因子-1 水平。

Eotaxin-1 Levels in Patients with Myocardial Infarction.

出版信息

Clin Lab. 2022 Mar 1;68(3). doi: 10.7754/Clin.Lab.2021.210806.

DOI:10.7754/Clin.Lab.2021.210806

Abstract

BACKGROUND

Acute myocardial infarction is one of the leading causes of morbidity and mortality worldwide. Eotaxin-1, an eosinophil-specific chemoattractant, has been shown to be overexpressed in human atherosclerotic lesions. Eotaxin-1 levels are higher in coronary artery disease patients than in healthy individuals. In this study, we aimed to determine the eotaxin-1 concentrations of patients with myocardial infarction and to investigate the role of eotaxin-1 in myocardial infarction.

METHODS

The study included 42 patients diagnosed with AMI (patients with suspected AMI based on history, physical examination, ECG, and biochemical markers and confirmed by angiography) and 40 healthy controls. Plasma eotaxin-1 levels were determined by enzyme-linked immunosorbent assay (ELISA).

RESULTS

Eotaxin-1, troponin-I, CK, and CKMB levels were statistically higher in the patient group than in the control group. ROC analysis demonstrated that eotaxin-1 gave a sensitivity of 93% and a specificity of 48% once the cutoff value was 341.6 pg/mL. Additionally, the ROC analysis showed that troponin I yielded a specificity of 100% and a sensitivity of 91% when the cutoff value was 0.025 µg/L.

CONCLUSIONS

Eotaxin-1/eosinophils appear to have a role in coronary artery disease independent of known risk factors. Accordingly, this study and recent studies suggest that eotaxin-1 may be useful in the diagnosis of AMI in addition to other cardiac markers.

摘要

背景

急性心肌梗死是全球发病率和死亡率的主要原因之一。嗜酸性粒细胞趋化因子-1（Eotaxin-1）是一种嗜酸性粒细胞特异性趋化因子，已被证明在人类动脉粥样硬化病变中过度表达。在冠心病患者中，Eotaxin-1 水平高于健康个体。在这项研究中，我们旨在确定心肌梗死患者的 Eotaxin-1 浓度，并研究 Eotaxin-1 在心肌梗死中的作用。

方法

该研究纳入了 42 名确诊为急性心肌梗死的患者（根据病史、体检、心电图和生化标志物怀疑患有急性心肌梗死，并通过血管造影证实）和 40 名健康对照者。通过酶联免疫吸附试验（ELISA）测定血浆 Eotaxin-1 水平。

结果

与对照组相比，患者组的 Eotaxin-1、肌钙蛋白 I、CK 和 CKMB 水平均统计学升高。ROC 分析表明，当 cutoff 值为 341.6 pg/mL 时，Eotaxin-1 的灵敏度为 93%，特异性为 48%。此外，ROC 分析显示，当 cutoff 值为 0.025 µg/L 时，肌钙蛋白 I 的特异性为 100%，灵敏度为 91%。