SARS-CoV-2 血清转换是否是儿童严重和急性精神症状的危险因素？
Is SARS-CoV-2 seroconversion a risk factor for severe and acute psychiatric symptoms in children?
机构信息
Child and Adolescent Psychiatry Department, Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Paris, France.
Paris University, Paris, France.
出版信息
Neuropsychopharmacol Rep. 2022 Jun;42(2):218-220. doi: 10.1002/npr2.12236. Epub 2022 Mar 8.
AIMS
Since the beginning of the COVID pandemic, studies reported an increase in children's mental health issues and questioned the impact of SARS-CoV-2 on psychiatric symptoms.
METHODS
We compared COVID seroconversion in children hospitalized with acute, severe psychiatric symptoms (n = 52) with the sex- and age-matched control group (n = 52) living in the same low-income geographic area and sampled during the same time period.
RESULTS
Contrary to our hypothesis, we observed less seroconverted children with psychiatric conditions 9.61% (95% CI, 3.59-21.80) vs 34.61% (95% CI, 22.33-49.16; χ = 14.7, P = 1.24E-4; OR = 0.20; 95% CI, 0.05-0.64).
CONCLUSION
This suggests a lower direct impact of SARS-CoV-2 compared with the impact of mitigation strategies on psychiatric symptom deterioration in children reported since early stages of the pandemic.
目的
自 COVID 大流行开始以来，研究报告称儿童心理健康问题有所增加，并质疑 SARS-CoV-2 对精神症状的影响。
方法
我们比较了在同一低收入地理区域住院且患有急性严重精神症状（n=52）的儿童与在同一时期采样的性别和年龄匹配的对照组（n=52）的 COVID 血清转换情况。
结果
与我们的假设相反，我们观察到患有精神疾病的血清转换儿童较少，为 9.61%（95%CI，3.59-21.80），而对照组为 34.61%（95%CI，22.33-49.16；χ²=14.7，P=1.24E-4；OR=0.20；95%CI，0.05-0.64）。
结论
这表明 SARS-CoV-2 的直接影响低于大流行早期报告的缓解策略对儿童精神症状恶化的影响。
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