N-乙酰半胱氨酸对恢复生物标志物的影响：一项对照试验的系统评价和荟萃分析。
The effects of N-acetylcysteine on recovery biomarkers: A systematic review and meta-analysis of controlled trials.
机构信息
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
J Food Biochem. 2022 Jul;46(7):e14116. doi: 10.1111/jfbc.14116. Epub 2022 Mar 9.
N-acetylcysteine (NAC) is one of the antioxidant supplements which is thought to improve recovery. Existing studies regarding NAC and recovery presented conflicting results. This systematic review and meta-analysis evaluated the existing trials and determined the efficacy of acute and chronic NAC administration on recovery biomarkers. PubMed, Web of Science, and Scopus were searched up to July 2021. The random effects or fixed effects model was applied in the meta-analysis. Sensitivity and subgroup analyses were performed. In case of the presence of publication bias, standard methods were applied. The meta-analysis comprised 37 papers (1,388 participants). All included studies were in English language. Acute NAC administration indicated no significant effects on lactate, pH, VO , and CPK-MB ([SMD = -0.06 mmol/L; 95% CI: -0.40, 0.28; p = .714], [SMD = 0.17; 95% CI: -0.28, 0.62; p = .454], [SMD = -0.11 L/min; 95% CI: -0.63, 0.41; p = .686], and [SMD = -0.19 units/L; 95% CI: -0.62, 0.24; p = .395]). Additionally, no evidence of significant influence of chronic NAC administration on lactate, pH, VO , and CK was revealed ([SMD = 0.01 mmol/L; 95% CI: -0.25, 0.27; p = .950], [SMD = -0.51; 95% CI: -1.73, 0.70; p = .424], [SMD = -0.18 L/min; 95% CI: -0.56, 0.20; p = .361], and [SMD = -0.04 units/L; 95% CI: -0.36, 0.29; p = .821]). No considerable effect of NAC on recovery was found. PRACTICAL APPLICATIONS: Previous studies on the influence of NAC administration on recovery biomarkers have presented conflicting results. This systematic review and meta-analysis offers a broad range of detailed information on the influence of chronic and acute NAC supplementation outcomes regarding recovery biomarkers. Overall, the results support that NAC supplementation may not be effective in improving recovery biomarkers. However, subgroup analyses based on NAC dosage indicated the meaningful effect of NAC on CK-MB at the dosage of ≥100 mg/kg.
N-乙酰半胱氨酸（NAC）是一种抗氧化补充剂，被认为可以促进恢复。现有的关于 NAC 和恢复的研究结果相互矛盾。本系统评价和荟萃分析评估了现有的试验，并确定了急性和慢性 NAC 给药对恢复生物标志物的疗效。检索了 PubMed、Web of Science 和 Scopus 数据库，检索时间截至 2021 年 7 月。荟萃分析采用随机效应或固定效应模型。进行了敏感性和亚组分析。如果存在发表偏倚，则应用标准方法。荟萃分析纳入了 37 篇论文（1388 名参与者）。所有纳入的研究均为英文。急性 NAC 给药对乳酸、pH 值、VO2 和 CPK-MB 没有显著影响([SMD=-0.06mmol/L;95%CI:-0.40,0.28;p=0.714]，[SMD=0.17;95%CI:-0.28,0.62;p=0.454]，[SMD=-0.11L/min;95%CI:-0.63,0.41;p=0.686]，[SMD=-0.19units/L;95%CI:-0.62,0.24;p=0.395])。此外，没有证据表明慢性 NAC 给药对乳酸、pH 值、VO2 和 CK 有显著影响([SMD=0.01mmol/L;95%CI:-0.25,0.27;p=0.950]，[SMD=-0.51;95%CI:-1.73,0.70;p=0.424]，[SMD=-0.18L/min;95%CI:-0.56,0.20;p=0.361]，[SMD=-0.04units/L;95%CI:-0.36,0.29;p=0.821])。NAC 对恢复没有明显影响。实用意义：以前关于 NAC 给药对恢复生物标志物影响的研究结果相互矛盾。本系统评价和荟萃分析提供了广泛而详细的信息，说明慢性和急性 NAC 补充对恢复生物标志物的影响。总的来说，结果支持 NAC 补充剂可能不会有效改善恢复生物标志物。然而，基于 NAC 剂量的亚组分析表明，NAC 在剂量≥100mg/kg 时对 CK-MB 有显著影响。
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