Wang Ling, Zheng Wenya, Yang Jinxin, Ali Anwar, Qin Hong
Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha 410078, China.
Nutrients. 2022 Feb 23;14(5):954. doi: 10.3390/nu14050954.
(AM) is a food and medicinal homologous plant. The current research is aimed to investigate the beneficial effects and mechanisms of AM in treating acquired hyperlipidemia. The network pharmacology and bioinformatics analysis results showed 481 AM-related targets and 474 acquired hyperlipidemia-associated targets, and 101 candidate targets were obtained through the intersection, mainly enriched in endocrine resistance, AGE-RAGE in diabetic complications and p53 signaling pathways. , , , were determined as the candidate active components of AM in the treatment of acquired hyperlipidemia. Moreover, key targets of AM, namely, AKT serine/threonine kinase 1 (AKT1), vascular endothelial growth factor A (VEGFA), cyclin D1 (CCND1) and estrogen receptor 1 (ESR1), were screened out, which were closely related to adipogenesis, fatty acid metabolism and bile acid metabolism. The subsequent animal experiments showed that AM extract treatment improved the lipid profiles of the high-fat diet (HFD)-fed mice by reducing lipogenesis and increasing lipolysis and lipid β-oxidation, which were associated with the downregulating of AKT1 and CCND1, and the upregulating of VEGFA and ESR1 in liver and adipose tissue. Overall, AM alleviated acquired hyperlipidemia through regulating lipid metabolism, and AKT1, VEGFA, CCND1 and ESR1 might be the key targets.
紫穗槐是一种药食同源植物。当前的研究旨在探究紫穗槐在治疗后天性高脂血症方面的有益作用及机制。网络药理学和生物信息学分析结果显示，有481个与紫穗槐相关的靶点和474个与后天性高脂血症相关的靶点，通过交集得到101个候选靶点，主要富集在内分泌抵抗、糖尿病并发症中的晚期糖基化终末产物受体（AGE-RAGE）和p53信号通路。[此处原文缺失具体成分名称]被确定为紫穗槐治疗后天性高脂血症的候选活性成分。此外，筛选出了紫穗槐的关键靶点，即丝氨酸/苏氨酸蛋白激酶1（AKT1）、血管内皮生长因子A（VEGFA）、细胞周期蛋白D1（CCND1）和雌激素受体1（ESR1），它们与脂肪生成、脂肪酸代谢和胆汁酸代谢密切相关。随后的动物实验表明，紫穗槐提取物处理通过减少脂肪生成、增加脂肪分解和脂质β-氧化改善了高脂饮食喂养小鼠的血脂谱，这与肝脏和脂肪组织中AKT1和CCND1的下调以及VEGFA和ESR1的上调有关。总体而言，紫穗槐通过调节脂质代谢减轻了后天性高脂血症，AKT1、VEGFA、CCND1和ESR1可能是关键靶点。
