Department of Pharmacology & Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido Str., New Orleans, LA 70112, USA.
Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Nutrients. 2022 Mar 7;14(5):1126. doi: 10.3390/nu14051126.
Soy infant formula which is fed to over half a million infants per year contains isoflavones such as genistein, which have been shown to be estrogenic at high concentrations. The developing testis is sensitive to estrogens, raising concern that the use of soy formulas may result in male reproductive toxicity. In the current study, male White-Dutch Landrace piglets received either sow milk (Sow), or were provided milk formula (Milk), soy formula (Soy), milk formula supplemented with 17-beta-estradiol (2 mg/kg/d) (M + E2) or supplemented with genistein (84 mg/L of diet; (M + G) from postnatal day 2 until day 21. E2 treatment reduced testis weight (p < 0.05) as percentage of body weight, significantly suppressed serum androgen concentrations, increased tubule area, Germ cell and Sertoli cell numbers (p < 0.05) relative to those of Sow or Milk groups. Soy formula had no such effects relative to Sow or Milk groups. mRNAseq revealed 103 differentially expressed genes in the M + E2 group compared to the Milk group related to endocrine/metabolic disorders. However, little overlap was observed between the other treatment groups. These data suggest soy formula is not estrogenic in the male neonatal piglet and that soy formula does not significantly alter male reproductive development.
每年有超过五十万婴儿食用的大豆婴儿配方奶粉含有大豆异黄酮，如染料木黄酮，在高浓度下已被证明具有雌激素活性。正在发育的睾丸对雌激素敏感，这让人担心使用大豆配方可能会导致男性生殖毒性。在目前的研究中，雄性大白荷兰长白猪仔猪接受母猪奶（Sow）或提供配方奶（Milk）、大豆配方奶（Soy）、添加 17-β-雌二醇（2 mg/kg/d）的配方奶（M + E2）或添加染料木黄酮（饮食中的 84 mg/L；（M + G）从产后第 2 天到第 21 天。E2 处理降低了睾丸重量（p < 0.05）作为体重的百分比，显著抑制了血清雄激素浓度，增加了管腔面积、生殖细胞和支持细胞数量（p < 0.05）相对于 Sow 或 Milk 组。与 Sow 或 Milk 组相比，大豆配方奶没有这种作用。mRNAseq 揭示了与 Milk 组相比，M + E2 组有 103 个差异表达基因与内分泌/代谢紊乱有关。然而，其他治疗组之间观察到的重叠很少。这些数据表明，大豆配方奶在雄性新生仔猪中没有雌激素活性，并且大豆配方奶不会显著改变男性生殖发育。
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