循环记忆 T 细胞升高先于黑色素瘤免疫治疗毒性。
Elevated circulating memory T cells precede immunotherapy toxicities in melanoma.
机构信息
UMass Chan Medical School, Worcester, MA, USA.
Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Trends Cancer. 2022 May;8(5):347-349. doi: 10.1016/j.trecan.2022.02.008. Epub 2022 Mar 8.
Immune checkpoint inhibitor (ICI) therapy for cancer is limited by inflammatory toxicities that can be fatal. Predicting who will develop these toxicities is a critical clinical problem. Lozano et al. found that circulating CD4+ memory T cells and T cell receptor (TCR) diversity correlate with the risk of ICI toxicity, suggesting an important role for CD4+ memory T cells in the initiation of these inflammatory adverse events.
免疫检查点抑制剂（ICI）治疗癌症受到可致命的炎症毒性的限制。预测哪些患者会出现这些毒性是一个关键的临床问题。Lozano 等人发现，循环 CD4+记忆 T 细胞和 T 细胞受体（TCR）多样性与 ICI 毒性风险相关，这表明 CD4+记忆 T 细胞在这些炎症不良事件的发生中起着重要作用。
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