听觉中枢神经系统主要核团中的γ-氨基丁酸免疫反应性

GABA immunoreactivity in the primary nuclei of the auditory central nervous system.

作者信息

Peyret D, Geffard M, Aran J M

出版信息

Hear Res. 1986;23(2):115-21. doi: 10.1016/0378-5955(86)90008-0.

Abstract

Structures containing gamma-amino butyric acid (GABA) were investigated in the guinea pig cochlear nuclei and superior olivary complexes by means of an immunohistochemical procedure using an antibody directed against GABA. Immunoreactivity was observed in cell bodies of the superficial layers of the ventral and dorsal cochlear nuclei, in lateral superior olive, in some neurons of the medial superior olive, in lateral preolivary nuclei and in the lateral nucleus of the trapezoid body. Fibers and profiles exhibiting GABA immunoreactivity were found in almost all regions of the lower auditory pathways. The abundance of GABA in these regions indicates an important role of this inhibitory amino-acid in the auditory brainstem.

摘要

运用一种针对γ-氨基丁酸（GABA）的抗体，通过免疫组织化学方法，对豚鼠耳蜗核和上橄榄复合体中含有GABA的结构进行了研究。在腹侧和背侧耳蜗核表层的细胞体、外侧上橄榄核、内侧上橄榄核的一些神经元、外侧橄榄前核以及梯形体外侧核中观察到了免疫反应性。在听觉传导通路下部的几乎所有区域都发现了显示GABA免疫反应性的纤维和细胞轮廓。这些区域中GABA的丰富含量表明这种抑制性氨基酸在听觉脑干中起着重要作用。