Ghandourh Wsam, Holloway Lois, Batumalai Vikneswary, Chlap Phillip, Field Matthew, Jacob Susannah
South Western Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Liverpool and Macarthur Cancer Therapy Centres, Sydney, New South Wales, Australia.
Clin Transl Radiat Oncol. 2022 Mar 5;34:7-14. doi: 10.1016/j.ctro.2022.03.001. eCollection 2022 May.
Radiotherapy utilisation rates considerably vary across different countries and service providers, highlighting the need to establish reliable benchmarks against which utilisation rates can be assessed. Here, optimal utilisation rates of Stereotactic Ablative Body Radiotherapy (SABR) for lung cancer are estimated and compared against actual utilisation rates to identify potential shortfalls in service provision.
An evidence-based optimal utilisation model was constructed after reviewing practice guidelines and identifying indications for lung SABR based on the best available evidence. The proportions of patients likely to develop each indication were obtained, whenever possible, from Australian population-based studies. Sensitivity analysis was performed to account for variations in epidemiological data. Practice pattern studies were reviewed to obtain actual utilisation rates.
A total of 6% of all lung cancer patients were estimated to optimally require SABR at least once during the course of their illness (95% CI: 4-6%). Optimal utilisation rates were estimated to be 32% for stage I and 10% for stage II NSCLC. Actual utilisation rates for stage I NSCLC varied between 6 and 20%. For patients with inoperable stage I, 27-74% received SABR compared to the estimated optimal rate of 82%.
The estimated optimal SABR utilisation rates for lung cancer can serve as useful benchmarks to highlight gaps in service delivery and help plan for more adequate and efficient provision of care. The model can be easily modified to determine optimal utilisation rates in other populations or updated to reflect any changes in practice guidelines or epidemiological data.
不同国家和服务提供商之间的放射治疗利用率差异很大,这凸显了建立可靠基准以评估利用率的必要性。在此,我们估计了立体定向消融体部放射治疗(SABR)用于肺癌的最佳利用率,并与实际利用率进行比较,以确定服务提供方面的潜在不足。
在审查实践指南并根据现有最佳证据确定肺癌SABR的适应症后,构建了一个基于证据的最佳利用模型。尽可能从澳大利亚基于人群的研究中获取可能出现每种适应症的患者比例。进行了敏感性分析以考虑流行病学数据的变化。审查实践模式研究以获得实际利用率。
估计所有肺癌患者中有6%在病程中至少最佳地需要一次SABR(95%CI:4-6%)。I期非小细胞肺癌(NSCLC)的最佳利用率估计为32%,II期为10%。I期NSCLC的实际利用率在6%至20%之间。对于无法手术的I期患者,27%-74%接受了SABR,而估计的最佳率为82%。
估计的肺癌SABR最佳利用率可作为有用的基准,以突出服务提供方面的差距,并有助于规划更充分和高效的护理提供。该模型可以很容易地修改以确定其他人群的最佳利用率,或更新以反映实践指南或流行病学数据的任何变化。