酶法实现喹啉及其衍生物的选择性氧化。

Enzymatic approaches to site-selective oxidation of quinoline and derivatives.

机构信息

Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, 563000 Zunyi, People's Republic of China.

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, 563000 Zunyi, People's Republic of China.

出版信息

Org Biomol Chem. 2022 Mar 30;20(13):2580-2600. doi: 10.1039/d2ob00200k.

DOI:10.1039/d2ob00200k

PMID:35290426

Abstract

Enzyme-mediated oxidation has been a green and efficient strategy for preparation of derivative chemicals from quinoline and its structural analogues. Herein, we report the progress made to date in enzymatic methods to oxidation of the pyridine moieties of quinoline and its structural analogues 1,2,3,4-tetrahydroquinoline, isoquinoline and 1,2,3,4-tetrahydroisoquinoline, including whole cell- and isolated enzyme-based transformations. In addition, methods to tune the site selectivity of the course of enzymatic transformation are also addressed, in particular the protein engineering approaches.

摘要

酶介导的氧化反应是一种绿色且高效的策略，可用于从喹啉及其结构类似物中制备衍生化学品。本文综述了目前在酶法氧化喹啉及其结构类似物 1,2,3,4-四氢喹啉、异喹啉和 1,2,3,4-四氢异喹啉的吡啶环方面的进展，包括全细胞和分离酶转化。此外，还讨论了调节酶转化过程中位点选择性的方法，特别是蛋白质工程方法。