Department of Gastroenterology, Central Clinical School, Monash University and Alfred Health, Level 6, 99 Commercial Road, Melbourne, VIC 3004, Australia.
J Nutr Sci. 2022 Feb 21;11:e15. doi: 10.1017/jns.2022.9. eCollection 2022.
Resistant starch 2 (RS2) may offer therapeutic value to irritable bowel syndrome (IBS) patients particularly in combination with minimally fermented fibre, but tolerability data are lacking. The present study evaluated the tolerability of RS2, sugarcane bagasse and their combination in IBS patients and healthy controls. Following baseline, participants consumed the fibres in escalating doses lasting 3 d each: RS2 (10, 15 and 20 g/d); sugarcane bagasse (5, 10 and 15 g/d); and their combination (20, 25 and 30 g/d). Gastrointestinal symptoms were assessed daily. Six IBS patients and five controls were recruited. No differences in overall symptoms from baseline were found across the fibre doses (IBS, = 0⋅586; controls, = 0⋅687). For IBS patients, all RS2 doses led to increased bloating. One IBS patient did not tolerate the low combination dose and another the high sugarcane bagasse dose. Supplementation of RS2 ≤ 20 g/d caused mild symptoms and was generally tolerated in IBS patients even when combined with minimally fermented fibre.
抗性淀粉 2（RS2）可能对肠易激综合征（IBS）患者具有治疗价值，尤其是与低发酵纤维联合使用时，但缺乏耐受性数据。本研究评估了 RS2、甘蔗渣及其组合在 IBS 患者和健康对照者中的耐受性。在基线后，参与者以每天持续 3 天的递增剂量摄入纤维：RS2（10、15 和 20 g/d）；甘蔗渣（5、10 和 15 g/d）；和它们的组合（20、25 和 30 g/d）。每天评估胃肠道症状。招募了 6 名 IBS 患者和 5 名对照者。在纤维剂量下，IBS 患者（ = 0.586；对照组， = 0.687）的总体症状与基线相比无差异。对于 IBS 患者，所有 RS2 剂量均导致腹胀增加。一名 IBS 患者不能耐受低剂量组合，另一名患者不能耐受高剂量甘蔗渣。RS2 补充量≤20 g/d 会引起轻微症状，即使与低发酵纤维联合使用，也通常能被 IBS 患者耐受。
