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一种具有与间质性膀胱炎/膀胱疼痛综合征相似表型特征的雌性大鼠模型。

A Model in Female Rats With Phenotypic Features Similar to Interstitial Cystitis/Bladder Pain Syndrome.

作者信息

Ness Timothy J, DeWitte Cary, DeBerry Jennifer J, Hart Morgan P, Clodfelder-Miller Buffie, Gu Jianguo G, Ling Jennifer, Randich Alan

机构信息

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.

出版信息

Front Pain Res (Lausanne). 2021 Dec 7;2:791045. doi: 10.3389/fpain.2021.791045. eCollection 2021.

DOI:10.3389/fpain.2021.791045
PMID:35295535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8915626/
Abstract

This report describes methodological and exploratory investigations of the zymosan-induced neonatal bladder inflammation (NBI) model of interstitial cystitis/bladder pain syndrome (IC/BPS) in female rats. These results validate and extend the currently employed model by evaluating critical timepoints for obtaining treatment effects and identified that a second insult as an adult including repeat intravesical zymosan, intravesical lipopolysaccharide, acute footshock stress, neuropathic nociception (facial) or somatic inflammation (hindpaw) all resulted in magnified visceromotor responses to urinary bladder distension (UBD) in rats which had experienced NBI when compared with their controls. NBI also resulted in increased tone and reactivity of pelvic floor musculature to UBD, as well as increased responsiveness to intravesical potassium chloride solutions, abnormal anxiety measures (elevated plus maze) and an increased number of submucosal petechial hemorrhages following 30 min of hydrodistension of the bladder. These phenotypic findings have correlates to the clinical features of IC/BPS in humans and so support use of this model system to examine mechanisms of and treatments for IC/BPS.

摘要

本报告描述了雌性大鼠中酵母聚糖诱导的间质性膀胱炎/膀胱疼痛综合征（IC/BPS）新生儿膀胱炎症（NBI）模型的方法学和探索性研究。这些结果通过评估获得治疗效果的关键时间点，验证并扩展了目前使用的模型，并确定成年后的第二次损伤，包括重复膀胱内注射酵母聚糖、膀胱内注射脂多糖、急性足底电击应激、神经性伤害感受（面部）或躯体炎症（后爪），与对照组相比，所有这些都会导致经历过NBI的大鼠对膀胱扩张（UBD）的内脏运动反应放大。NBI还导致盆底肌肉组织对UBD的张力和反应性增加，以及对膀胱内氯化钾溶液的反应性增加、异常焦虑测量（高架十字迷宫）和膀胱水扩张30分钟后黏膜下瘀点出血数量增加。这些表型发现与人类IC/BPS的临床特征相关，因此支持使用该模型系统来研究IC/BPS的机制和治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d949/8915626/aeff159e26df/fpain-02-791045-g0010.jpg
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