Sung M, Jee H M, Kim J H, Ha E K, Shin Y H, Kim J H, Lim D H, Han M Y
Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, Republic of Korea.
Eur Rev Med Pharmacol Sci. 2022 Mar;26(5):1640-1647. doi: 10.26355/eurrev_202203_28232.
Previous studies on the relationship of bisphenol-A (BPA) with fractional exhaled nitric oxide (FeNO) had conflicting results, suggesting that other factors may modulate this relationship. Thus, we investigated the modulating effect of vitamin D on the relationship of BPA with FeNO in children.
This study recruited 432 children (10 to 12 years old) from the general pediatric population of Korea between June and July 2017. We conducted measurements of urinary BPA, serum vitamin D, specific serum IgE, FeNO, and data from impulse oscillometry (reactance area [AX], airway resistance at 5 Hz [Rrs5] and 20 Hz [Rrs10], and the difference of Rrs5 and Rrs20 [Rrs5-20]).
Serum vitamin D (adjusted β =- 0.014, p=0.002) and urinary BPA (β = 0.006, p<0.001) level was significantly associated with FeNO. Urinary BPA level was significantly associated with FeNO in children with low vitamin D levels (≤23 ng/mL; αβ = 0.006, p < 0.001), but not in children with high vitamin D levels (>23 ng/mL). The interaction of vitamin D and BPA had a significant effect on FeNO (pint = 0.005). There was no relationship with the airway lung function (Rrs5, AX, and Rrs5-20) to serum vitamin D and urinary BPA level. Vitamin D ameliorated the BPA-mediated increase of FeNO in children.
These results suggest that children with low vitamin D levels may be more susceptible to airway inflammation due to BPA.
先前关于双酚A（BPA）与呼出气一氧化氮分数（FeNO）关系的研究结果相互矛盾，这表明其他因素可能会调节这种关系。因此，我们研究了维生素D对儿童中BPA与FeNO关系的调节作用。
本研究于2017年6月至7月从韩国普通儿科人群中招募了432名儿童（10至12岁）。我们对尿BPA、血清维生素D、特异性血清IgE、FeNO进行了测量，并收集了脉冲振荡法的数据（电抗面积[AX]、5Hz时的气道阻力[Rrs5]和20Hz时的气道阻力[Rrs10]，以及Rrs5和Rrs20的差值[Rrs5-20]）。
血清维生素D（校正β=-0.014，p=0.002）和尿BPA水平（β=0.006，p<0.001）与FeNO显著相关。在维生素D水平低（≤23ng/mL）的儿童中，尿BPA水平与FeNO显著相关（αβ=0.006，p<0.001），但在维生素D水平高（>23ng/mL）的儿童中则不然。维生素D和BPA的相互作用对FeNO有显著影响（p交互=0.005）。血清维生素D和尿BPA水平与气道肺功能（Rrs5、AX和Rrs5-20）无关。维生素D减轻了儿童中BPA介导的FeNO升高。
这些结果表明，维生素D水平低的儿童可能因BPA而更容易发生气道炎症。
