介导异染色质：FACT 在染色质沉默中的新功能。

Chaperoning heterochromatin: new roles of FACT in chromatin silencing.

机构信息

Physiological Chemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany.

Physiological Chemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany; Institute for Genetics, Justus-Liebig University Giessen, 35392 Giessen, Germany.

出版信息

Trends Genet. 2022 Jul;38(7):646-649. doi: 10.1016/j.tig.2022.02.011. Epub 2022 Mar 16.

DOI:10.1016/j.tig.2022.02.011

PMID:35303999

Abstract

The multitasking histone chaperone FACT (FAcilitates Chromatin Transcription) contributes to actively transcribed euchromatin and repressed heterochromatin. However, its precise role in gene silencing has remained obscure. Here, we discuss new insights into the silent chromatin functions and recruitment mechanisms of FACT, and their possible implications in cell identity and cancer.

摘要

多功能组蛋白伴侣 FACT（促进染色质转录）有助于活跃转录的常染色质和受抑制的异染色质。然而，其在基因沉默中的确切作用仍然不清楚。在这里，我们讨论了 FACT 参与沉默染色质功能和募集机制的新见解，以及它们在细胞身份和癌症中的可能意义。