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强功率、组合波长(810、940 和 1060nm)半导体激光治疗深色皮肤 III-IV 型毛发的安全性和疗效:单中心初步研究。

Safety and efficacy for hair removal in dark skin types III and IV with a high-powered, combined wavelength (810, 940 and 1060 nm) diode laser: A single-site pilot study.

机构信息

Tennessee Clinical Research Center, Nashville, Tennessee, USA.

Clinical and Scientific Department at Cocoon Medical, Barcelona, Spain.

出版信息

J Cosmet Dermatol. 2022 May;21(5):1979-1985. doi: 10.1111/jocd.14926. Epub 2022 Apr 6.

Abstract

BACKGROUND

Previous studies have demonstrated the superior efficacy of a high-power diode laser (4800 W) with a wavelength of 810 nm over others with less power and the same wavelength, while also being safe and comfortable for the patient. However, the use of this laser is limited on dark skin.

OBJECTIVES

This study aims to compare the efficacy, safety, and comfort of a 4800 W diode laser (810 nm) with that of the new Blend diode laser (810 nm, 940 nm, and 1064 nm). Furthermore, the study aims to demonstrate that the Blend diode laser delivers better results on darker skin.

MATERIALS AND METHODS

A 810 nm diode laser was compared with the Blend diode laser (810, 940 and 1064 nm) (Primelase, Cocoon Medical). A side-by-side comparative study was carried out over three sessions involving fourteen participants with skin types III and IV, with evaluation of the results 6 months after treatment. The study was performed at the Tennessee Clinical Research Center, Nashville, Tennessee, USA. This evaluation was based on efficacy, safety, comfort, and participant satisfaction.

RESULTS

Blend diode laser treatments were performed with fluences 40% (SE = 0.04%) higher than those of the 810 nm. Besides mild-to-moderate transient discomfort during the procedure, the Blend diode laser also produced an increased pricking sensation that was 1.8 points higher on a 10-point scale (p < 0.05), due to the higher fluence used. Hair reduction was 12% higher with the Blend diode laser, with a confidence level of 70%. Moreover, participants were more satisfied with the results of the Blend diode laser than with the diode laser (50% very satisfied vs. 36%, respectively). No long-term adverse effects were observed.

CONCLUSIONS

The new Blend diode laser has been shown to be more effective and satisfactory than 810 nm diode laser on dark skin types III and IV, while also being safe and comfortable for participants.

摘要

背景

先前的研究表明,与功率较低且波长相同的其他激光相比,波长为 810nm 的高功率二极管激光(4800W)具有更好的疗效,并且对患者安全且舒适。然而,这种激光在深色皮肤中的应用受到限制。

目的

本研究旨在比较 4800W 二极管激光(810nm)与新型混合二极管激光(810nm、940nm 和 1064nm)的疗效、安全性和舒适性。此外,本研究旨在证明混合二极管激光在较深肤色上能带来更好的效果。

材料和方法

将 810nm 二极管激光与混合二极管激光(810、940 和 1064nm)(Primelase,Cocoon Medical)进行对比。在三个疗程中,对 14 名皮肤类型为 III 型和 IV 型的参与者进行了并排比较研究,在治疗后 6 个月评估结果。该研究在美国田纳西州纳什维尔的田纳西临床研究中心进行。该评估基于疗效、安全性、舒适性和参与者满意度。

结果

混合二极管激光治疗的脉宽比 810nm 高 40%(SE=0.04%)。除了手术过程中出现轻微到中度的短暂不适外,混合二极管激光还产生了更高的刺痛感,在 10 分制中增加了 1.8 分(p<0.05),这是由于使用了更高的脉宽。与二极管激光相比,混合二极管激光的毛发减少了 12%,置信水平为 70%。此外,参与者对混合二极管激光的效果比二极管激光更满意(分别为 50%非常满意和 36%)。未观察到长期不良反应。

结论

新型混合二极管激光在 III 型和 IV 型深色皮肤中的疗效优于 810nm 二极管激光,同时对参与者安全且舒适。

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