Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Environ Toxicol Pharmacol. 2022 May;92:103852. doi: 10.1016/j.etap.2022.103852. Epub 2022 Mar 17.
Copper oxide (CuO) NPs are widely used and subsequently released into terrestrial ecosystems. In the present study, bioaccumulation and effects of CuO NPs and dissolved Cu was examined in the fruit fly Drosophila melanogaster after 7 and 10 days dietary exposure at concentrations ranging between 0.09 and 1.2 mg Cu ml for dissolved Cu and between 0.2 and 11 mg Cu ml for CuO NPs. Both Cu forms were bioaccumulated and affected survival and climbing in flies, but not egg-to-adult development. Dissolved Cu caused higher mortality than CuO NPs (CuO NPs 10-days LC was 2 times higher), whereas NPs affected climbing and decreased the number of eggs laid per female, potentially affecting fruit fly population size in terrestrial environments. Thus, the study indicates that CuO NPs might cause effects that are different from dissolved Cu due to differences in the mechanism of uptake or toxicity. Therefore, we need to consider relevant sublethal endpoints when assessing these CuO NPs to ensure that we do not overlook long-term effects.
氧化铜（CuO）纳米颗粒被广泛使用，随后会释放到陆地生态系统中。在本研究中，我们在饮食暴露 7 天和 10 天后，用浓度范围在 0.09 至 1.2mgCu/ml（用于溶解态 Cu）和 0.2 至 11mgCu/ml（用于 CuO NPs）的条件下，研究了 CuO NPs 和溶解态 Cu 对黑腹果蝇的生物累积和影响。两种 Cu 形态都被生物累积，并影响了果蝇的存活和攀爬能力，但对卵到成虫的发育没有影响。溶解态 Cu 比 CuO NPs 造成更高的死亡率（CuO NPs 10 天 LC 高 2 倍），而 NPs 影响了攀爬能力并减少了每个雌蝇产卵的数量，可能会影响陆地环境中果蝇的种群规模。因此，本研究表明，由于摄取或毒性机制的差异，CuO NPs 可能会引起与溶解态 Cu 不同的影响。因此，在评估这些 CuO NPs 时，我们需要考虑相关的亚致死终点，以确保我们不会忽视长期影响。
