Hospital Nacional Dos de Mayo, Lima, Peru
ADIECS Association for the Development of Student Research in Health Sciences, Universidad Nacional Mayor de San Marcos, Lima, Peru
J Clin Res Pediatr Endocrinol. 2022 Aug 25;14(3):334-338. doi: 10.4274/jcrpe.galenos.2022.2022-12-9. Epub 2022 Mar 21.
The aim of this study was to evaluate the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS) with desmopressin for pediatric Cushing’s disease (CD).
We reviewed studies performed in children that evaluated the accuracy of BIPSS with desmopressin.
All included studies were case series of children with adrenocorticotropin hormone (ACTH)-dependent Cushing’s syndrome. The overall accuracy of BIPSS before stimulation was 84.1% (37/44), and after stimulation it was 92.3% (36/39). The overall lateralizing accuracy of BIPSS was 50.0%.
Considering that available evidence is limited, it appears that BIPSS with desmopressin stimulation is accurate for the diagnosis of pediatric CD, but its lateralizing accuracy is probably not suitable for pediatric clinical practice.
本研究旨在评估加压素刺激双侧岩下窦采样（BIPSS）对儿童库欣病（CD）的诊断准确性。
我们回顾了评估加压素刺激 BIPSS 准确性的儿童研究。
所有纳入的研究均为促肾上腺皮质激素（ACTH）依赖性库欣综合征患儿的病例系列研究。刺激前 BIPSS 的总体准确性为 84.1%（37/44），刺激后为 92.3%（36/39）。BIPSS 的总体定位准确性为 50.0%。
考虑到现有证据有限，加压素刺激 BIPSS 似乎可准确诊断儿童 CD，但定位准确性可能不适合儿科临床实践。
