Department of Paediatric Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Paediatric Endocrinology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ann Afr Med. 2022 Jan-Mar;21(1):16-20. doi: 10.4103/aam.aam_58_20.
The objective to investigate the effect of extreme body weight; obesity and undernutrition, on bone mineral density (BMD).
This study is a descriptive cross-sectional study carried between January and June of 2019, and included 224 children and adolescents without any comorbidities or chronic disease. Important data collected included anthropometrics, past medical and surgical history, history of medication intake, level of physical activity and pubertal assessment. Data entry and analysis were conducted using Statistical Package for Social Sciences version 24.
Gender distribution showed 48.2% were male and 51.8% were female. The mean age was 9.98 ± 3.5 years. Mean weight was 34.89 ± 18.2 kg. Mean BMD z-score was - 1.64 ± 1.4. Weight was considered to significantly correlate with BMD stature at a P = 0.014. Subjects who were underweight showed a lower mean BMD z-score of <-2 than those who were overweight/obese (mean BMD z-score = -1.60).
Both extremes of weight are considered a significant risk factor for the development of low BMD in children. We recommend the early recognition of weight aberrations and consequent aggressive intervention with strict lifestyle modifications to promote the development of maximum peak bone mass.
研究体重极端变化、肥胖和营养不良对骨密度（BMD）的影响。
本研究是一项 2019 年 1 月至 6 月进行的描述性横断面研究，共纳入 224 名无任何合并症或慢性疾病的儿童和青少年。收集的重要数据包括人体测量学、既往病史和手术史、用药史、身体活动水平和青春期评估。使用统计软件包 24 版进行数据录入和分析。
性别分布显示，男性占 48.2%，女性占 51.8%。平均年龄为 9.98 ± 3.5 岁。平均体重为 34.89 ± 18.2kg。平均 BMD z 评分为-1.64 ± 1.4。体重与 BMD 身高显著相关（P = 0.014）。体重不足的受试者 BMD z 评分明显低于超重/肥胖者（BMD z 评分均值为-1.60）。
体重的两个极端都被认为是儿童低 BMD 发育的重要危险因素。我们建议早期识别体重异常，并通过严格的生活方式改变进行积极干预，以促进最大峰值骨量的发育。
