Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Department of Medical Microbiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
BMC Infect Dis. 2022 Mar 22;22(1):278. doi: 10.1186/s12879-022-07276-8.
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, affecting about 80% of women up to the age of 50. The persistent infection of high risk-HPV types (HR-HPV) is the leading cause of cervical cancer, the fourth most common cancer of women. Therefore, we aimed to evaluate the frequency and typing of HPV in the genital lesions in the Iranian population.
This descriptive-analytic study was conducted on a population in the South-Khorasan province of Iran. All of the participants were sexually active and were checked for evident cervical warts. Biopsy samples were collected from various lesions, and all samples were tested for detection and genotyping of HPV using a reverse dot blot hybridization method (HPV direct flow CHIP).
In overall, 370 samples were evaluated; 10 cases (2.7%) were male and the rest were female. The mean age of patients was 33.3 ± 8.5 years, of which 48.1% were in the age range from 25 to 36 years. Among the samples, 345 (93.2%) were positive for HPV-DNA; the low risk HPV types (LR-HPV) and HR-HPV were identified among 80.9% and 15.5% of tissue samples, respectively. Among the LR-HPV, HPV-6, 11, 42 and 54 were the most common genotypes, and HPV-16 and 39 were prevalent HR-HPV types detected. The number of pregnancies, marriage age, and partner infection were not significantly related to the HPV types. Types 42 had a declining pattern toward aging, and HPV-11 was increasing toward aging.
The number of samples with HR-HPV was rather high. Due to the greater frequency of infection in the age range of 25-35 years, it is advised that all individuals referred to gynecological clinics at gestational age be tested for HPV types.
人乳头瘤病毒（HPV）是全球最常见的性传播感染，约 80%的 50 岁以下女性受到影响。高危型 HPV（HR-HPV）的持续感染是宫颈癌的主要病因，宫颈癌是女性第四大常见癌症。因此，我们旨在评估伊朗人群生殖器官病变中 HPV 的频率和类型。
这是一项在伊朗南呼罗珊省进行的描述性分析研究。所有参与者均有性行为，并检查明显的宫颈疣。从各种病变采集活检样本，所有样本均采用反向斑点印迹杂交法（HPV 直接流式 CHIP）检测和 HPV 基因型。
总共评估了 370 个样本，10 例（2.7%）为男性，其余为女性。患者的平均年龄为 33.3±8.5 岁，其中 48.1%的年龄在 25 至 36 岁之间。在样本中，345 个（93.2%）HPV-DNA 阳性；低危 HPV 类型（LR-HPV）和高危 HPV（HR-HPV）分别在 80.9%和 15.5%的组织样本中鉴定出来。在 LR-HPV 中，HPV-6、11、42 和 54 是最常见的基因型，HPV-16 和 39 是检测到的常见 HR-HPV 类型。怀孕次数、结婚年龄和伴侣感染与 HPV 类型无显著相关性。类型 42 随年龄增长呈下降趋势，HPV-11 随年龄增长呈上升趋势。
HR-HPV 样本数量相当高。由于 25-35 岁年龄组感染率较高，建议所有到妇科诊所就诊的孕妇都进行 HPV 类型检测。
