儿童急性早幼粒细胞白血病中的肥胖症：其流行率和预后意义是什么？
Obesity in children with acute promyelocytic leukemia: What is its prevalence and prognostic significance?
机构信息
Department of Pediatric Hematology/Oncology, Goryeb Children's Hospital of Morristown Medical Center, Morristown, New Jersey, USA.
AbbVie, Chicago, Illinois, USA.
出版信息
Pediatr Blood Cancer. 2022 Jun;69(6):e29613. doi: 10.1002/pbc.29613. Epub 2022 Mar 24.
OBJECTIVE
To compare outcomes of obese and nonobese pediatric patients with acute promyelocytic leukemia (APL) from the Cancer and Leukemia Group B trial (CALGB) 9710 and the Children's Oncology Group trial AAML0631.
METHODS
Data including demographics, adverse events, overall and event-free survival (EFS) were analyzed.
RESULTS
The prevalence of obesity was 34% on C9710 and 35% on AAML0631. There was significantly lower overall and EFS in the obese population on multivariable analysis on AAML0631 but not on CALGB 9710. Eleven patients died during therapy or in follow-up.
CONCLUSION
The prevalence of obesity is higher in pediatric patients with APL compared to the general population. The decreased EFS and OS in obese patients on AAML0631 suggest that the presence of obesity can influence outcomes using the most current treatment. These findings support the need for further research on the potential role of obesity in pediatric APL leukemogenesis.
目的
比较癌症和白血病组 B 试验（CALGB）9710 和儿童肿瘤组试验 AAML0631 中肥胖和非肥胖儿科急性早幼粒细胞白血病（APL）患者的结局。
方法
分析了包括人口统计学、不良事件、总生存率和无事件生存率（EFS）在内的数据。
结果
在 C9710 中肥胖的患病率为 34%，在 AAML0631 中为 35%。在 AAML0631 的多变量分析中，肥胖人群的总体生存率和 EFS 显著降低，但在 CALGB 9710 中则不然。11 名患者在治疗或随访期间死亡。
结论
与普通人群相比，儿科 APL 患者的肥胖患病率更高。AAML0631 中肥胖患者的 EFS 和 OS 降低表明，目前的治疗方法中肥胖的存在可能会影响结局。这些发现支持需要进一步研究肥胖在儿科 APL 白血病发生中的潜在作用。
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