Institute of Cardiovascular and Medical Sciences/British Heart Foundation, University of Glasgow, Glasgow, UK.
School of Engineering, Institute for Integrated Micro and Nano Systems, University of Edinburgh, Edinburgh, UK.
Adv Sci (Weinh). 2022 May;9(15):e2105285. doi: 10.1002/advs.202105285. Epub 2022 Mar 24.
Self-reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re-block after deployment due to a wound response called in-stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.
自我报告式可植入医疗器械是心血管医疗保健的未来。心血管并发症，如导致大多数心脏病发作和中风的动脉阻塞，通常采用惰性金属支架进行治疗，这些支架可重新开放受影响的血管。支架在部署后由于称为支架内再狭窄（ISR）的伤口反应而经常再次阻塞。在此，开发了一种可植入的微型传感器和遥测系统，该系统可以检测到这一过程，辨别与 ISR 相关的不同细胞类型，区分体外样本中所示的斑块下成分，并将血液与血栓区分开来，所有这些都在硅衬底上完成，使其适合整合到血管支架上。这项工作表明，与以前使用培养细胞的工作相比，微加工传感器可以在更接近生理条件的环境中提供临床相关信息。
