School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Cells. 2022 Mar 11;11(6):961. doi: 10.3390/cells11060961.
Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis. More than 300 withanolides were discovered from the plant family Solanaceae, exhibiting diverse functions. Notably, the relationship between oxidative stress, AKT signaling, and angiogenesis in withanolide treatments lacks comprehensive understanding. Here, we summarize connecting evidence related to oxidative stress, AKT signaling, and angiogenesis in the zebrafish model. A convenient vertebrate model monitored the in vivo effects of developmental and tumor xenograft angiogenesis using zebrafish embryos. The oxidative stress and AKT-signaling-modulating abilities of withanolides were highlighted in cancer treatments, which indicated that further assessments of their angiogenesis-modulating potential are necessary in the future. Moreover, targeting AKT for inhibiting AKT and its AKT signaling shows the potential for anti-migration and anti-angiogenesis purposes for future application to withanolides. This particularly holds for investigating the anti-angiogenetic effects mediated by the oxidative stress and AKT signaling pathways in withanolide-based cancer therapy in the future.
氧化应激和 AKT 丝氨酸/苏氨酸激酶 (AKT) 信号通路是细胞迁移、转移和血管生成的重要调节剂。超过 300 种茄属植物被发现具有不同的功能。值得注意的是，氧化应激、AKT 信号通路和血管生成在 Withanolide 治疗中的关系缺乏全面的了解。在这里，我们总结了与斑马鱼模型中氧化应激、AKT 信号通路和血管生成相关的连接证据。斑马鱼胚胎是一种方便的脊椎动物模型，可监测发育和肿瘤异种移植物血管生成的体内效应。氧化应激和 AKT 信号调节能力在癌症治疗中得到了强调，这表明未来有必要进一步评估它们对血管生成的调节潜力。此外，针对 AKT 抑制 AKT 及其 AKT 信号显示出在未来应用于 Withanolide 方面具有抗迁移和抗血管生成的潜力。特别是在未来的癌症治疗中，研究基于氧化应激和 AKT 信号通路的血管生成调节作用具有重要意义。
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