Jarosz-Lesz Anna, Brzozowska Aniceta, Maruniak-Chudek Iwona
Neonatology Unit, The Guardian Angels Hospital of the Brothers Hospitallers of St. John of God in Katowice, 40-211 Katowice, Poland.
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Children (Basel). 2022 Mar 21;9(3):443. doi: 10.3390/children9030443.
Copeptin (CTproAVP) is a stable by-product of arginine-vasopressin synthesis and reflects its secretion by the pituitary gland, considered as a potential new marker of dehydration. The objective of the study was to investigate CTproAVP measured after the first 48 h of postnatal life in relation to serum effective osmolality, urine osmolality, and vessels filling according to the following variables: delivery mode, postnatal weight loss, fluids administered intravenously to the mother, and fluids given orally to the neonate. A prospective observational study was conducted with 200 healthy term infants (53% male) enrolled. Serum CTproAVP concentrations were measured using the ELISA kit; haematocrit, urine osmolality, serum effective osmolality were assessed after 48 h of life. Sonographic measurements of inferior vena cava (IVC) and aorta (Ao) were performed and IVC/Ao ratios were calculated. No correlations were found between CTproAVP concentrations and both serum effective osmolality and urine osmolality. There was also no association between CTproAVP concentrations and vessel filling represented by IVC/Ao index at 48 h of life.
copeptin(CTproAVP)是精氨酸加压素合成的一种稳定副产物,反映垂体对其的分泌,被视为脱水的一种潜在新标志物。本研究的目的是根据以下变量,调查出生后48小时内测量的CTproAVP与血清有效渗透压、尿渗透压和血管充盈情况之间的关系:分娩方式、出生后体重减轻、静脉给予母亲的液体量以及口服给新生儿的液体量。对200名健康足月儿(53%为男性)进行了一项前瞻性观察研究。使用ELISA试剂盒测量血清CTproAVP浓度;出生48小时后评估血细胞比容、尿渗透压和血清有效渗透压。对下腔静脉(IVC)和主动脉(Ao)进行超声测量并计算IVC/Ao比值。未发现CTproAVP浓度与血清有效渗透压和尿渗透压之间存在相关性。在出生48小时时,CTproAVP浓度与以IVC/Ao指数表示的血管充盈情况之间也没有关联。