Wu Chih-Horng, Lai Tai-Shuan, Chen Yung-Ming, Chen Chyi-Mong, Yang Shun-Chung, Liang Po-Chin
Department of Medical Imaging, National Taiwan University Hospital, Taipei City 100, Taiwan.
Department of Internal Medicine, National Taiwan University Hospital, Taipei City 100, Taiwan.
Diagnostics (Basel). 2022 Mar 20;12(3):755. doi: 10.3390/diagnostics12030755.
Background: Polycystic kidney disease (PKD) is an inherited disorder characterized by renal cysts that may mask lean body loss. This study quantified and compared muscle mass by using computed tomography (CT) and magnetic resonance imaging (MRI) images between the PKD and control groups and correlated muscle mass with total kidney volume (TKV). Methods: We retrospectively enrolled patients who had a new diagnosis of PKD from May 2015 to May 2016. The CT and MRI images at the third lumbar level were processed to measure the total abdominal muscle (TAM) area for the diagnosis of sarcopenia, and TKV was estimated using the ellipsoid formula. Results: We included 37 women and 25 men (mean age: 50.40 years) in the PKD group. There was no difference in body mass index and albumin levels, but significant differences in creatinine level (p < 0.001), TAM area (p = 0.047), and TKV (p < 0.001), were noted between the two groups. A significantly negative correlation was observed between TKV and TAM area after adjustment for body height (r = −0.217, p = 0.003). Conclusions: CT and MRI images can accurately diagnose sarcopenia, which may be masked by cysts in patients with PKD.
多囊肾病（PKD）是一种遗传性疾病，其特征为肾囊肿，可能掩盖瘦体重的减少。本研究通过计算机断层扫描（CT）和磁共振成像（MRI）图像对PKD组和对照组的肌肉量进行量化和比较，并将肌肉量与总肾体积（TKV）进行关联分析。方法：我们回顾性纳入了2015年5月至2016年5月新诊断为PKD的患者。对第三腰椎水平的CT和MRI图像进行处理，以测量诊断肌肉减少症所需的腹部总肌肉（TAM）面积，并使用椭圆公式估算TKV。结果：PKD组纳入了37名女性和25名男性（平均年龄：50.40岁）。两组间体重指数和白蛋白水平无差异，但肌酐水平（p < 0.001）、TAM面积（p = 0.047）和TKV（p < 0.001）存在显著差异。调整身高后，TKV与TAM面积之间存在显著负相关（r = -0.217，p = 0.003）。结论：CT和MRI图像可准确诊断肌肉减少症，PKD患者的囊肿可能会掩盖这一情况。
