Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Data Science Center, College of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan.
Int J Environ Res Public Health. 2022 Mar 14;19(6):3395. doi: 10.3390/ijerph19063395.
Gout is the most common form of inflammatory arthritis in adults. Even though a link between gouty arthritis and type 2 diabetes mellitus (T2DM) has been reported, there is a limited understanding of the association between the anti-inflammatory agent colchicine and the risk of T2DM. This aim of this study was to assess the association between the use of colchicine and the risk of T2DM in an Asian cohort.
A retrospective cohort study was conducted using the National Health Insurance Research Database (NHIRD) in Taiwan from 2000 to 2013. The study cohorts comprised 3841 gouty patients using colchicine (the exposed cohort) and 7682 gouty patients not using colchicine (the unexposed -cohort). The primary outcome was incident DM. The hazard ratios (HRs) and 95% confidence intervals (CIs) derived from a Cox proportional regression model were used to assess the association between colchicine use and the risk of diabetes.
The cumulative incidence of T2DM was significantly lower in the exposed cohort (18.8%) than in the unexposed cohort (25.0%). The risk of T2DM was significantly lower in colchicine users than in non-users (adjusted HR, 0.74; 95% CI, 0.36-0.87). The inverse relationship between colchicine use and diabetes risk remained consistent across sex and age groups.
This cohort study provides longitudinal evidence that the use of colchicine is associated with a reduced risk of T2DM. This conclusion, however, needs to be interpreted cautiously given the lack of body mass index data in the NHIRD. Further studies are needed to determine the clinical implications of this study.
痛风是成年人中最常见的炎症性关节炎形式。尽管已经报道了痛风性关节炎与 2 型糖尿病（T2DM）之间存在关联，但对于秋水仙碱这种抗炎药物与 T2DM 风险之间的关联，人们的了解有限。本研究旨在评估亚洲队列中使用秋水仙碱与 T2DM 风险之间的关联。
本研究使用 2000 年至 2013 年台湾全民健康保险研究数据库（NHIRD）进行了回顾性队列研究。研究队列包括 3841 例使用秋水仙碱的痛风患者（暴露队列）和 7682 例未使用秋水仙碱的痛风患者（未暴露队列）。主要结局是糖尿病事件。使用 Cox 比例风险回归模型得出的风险比（HR）和 95%置信区间（CI）用于评估秋水仙碱使用与糖尿病风险之间的关联。
暴露队列的 T2DM 累积发生率（18.8%）明显低于未暴露队列（25.0%）。秋水仙碱使用者发生 T2DM 的风险明显低于非使用者（调整后的 HR，0.74；95%CI，0.36-0.87）。秋水仙碱使用与糖尿病风险之间的反比关系在性别和年龄组中保持一致。
这项队列研究提供了纵向证据，表明使用秋水仙碱与降低 T2DM 风险相关。然而，鉴于 NHIRD 中缺乏体重指数数据，因此需要谨慎解释这一结论。需要进一步的研究来确定本研究的临床意义。
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