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食管闭锁的长期消化道转归。

Long term digestive outcome of œsophageal atresia.

机构信息

Univ. Lille, Reference Centre for rare œsophageal diseases, CHU Lille, U 1286 INFINITE, F59000, Lille, France.

出版信息

Best Pract Res Clin Gastroenterol. 2022 Feb-Mar;56-57:101771. doi: 10.1016/j.bpg.2021.101771. Epub 2021 Oct 19.

Abstract

Œsophageal atresia is a rare neonatal malformation consisting in an interruption of the continuity of the œsophagus, with or without a tracheo-œsophageal fistula. Although mortality rate is now low and most cases can benefit from successful surgical repair soon after birth, morbidity -specially digestive and nutritional-remains high. Many of the adults born with œsophageal atresia will suffer from dysphagia, gastro-œsophageal reflux and/or œsophageal dysmotility, leading to nutritional consequences and quality of life impairment. Barrett's œsophagus, potential risk of œsophageal cancer as well as risk of anastomotic stenosis and eosinophilic œsophagitis justify transition to adulthood and a lifelong prolonged follow-up.

摘要

食管闭锁是一种罕见的新生儿畸形,表现为食管连续性中断,可伴有或不伴有气管食管瘘。尽管目前死亡率较低,大多数病例在出生后不久即可通过成功的手术修复获益,但发病率——特别是消化和营养方面——仍然很高。许多患有食管闭锁的成年人会出现吞咽困难、胃食管反流和/或食管动力障碍,导致营养后果和生活质量受损。巴雷特食管、潜在的食管癌风险以及吻合口狭窄和嗜酸性食管炎的风险,都需要向成年期过渡,并进行长期随访。

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