School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, Ireland.
Sci Rep. 2022 Mar 24;12(1):5121. doi: 10.1038/s41598-022-09044-9.
Additive Manufacturing is transforming how researchers and industrialists look to design and manufacture chemical devices to meet their specific needs. In this work, we report the first example of a flow reactor formed via the solid-state metal sheet lamination technique, Ultrasonic Additive Manufacturing (UAM), with directly integrated catalytic sections and sensing elements. The UAM technology not only overcomes many of the current limitations associated with the additive manufacturing of chemical reactionware but it also significantly increases the functionality of such devices. A range of biologically important 1, 4-disubstituted 1, 2, 3-triazole compounds were successfully synthesised and optimised in-flow through a Cu mediated Huisgen 1, 3-dipolar cycloaddition using the UAM chemical device. By exploiting the unique properties of UAM and continuous flow processing, the device was able to catalyse the proceeding reactions whilst also providing real-time feedback for reaction monitoring and optimisation.
增材制造正在改变研究人员和工业家设计和制造满足特定需求的化学设备的方式。在这项工作中，我们报告了首例通过固态金属片层压技术（超声增材制造，UAM）形成的流动反应器，该反应器具有直接集成的催化部分和传感元件。UAM 技术不仅克服了当前与化学反应器增材制造相关的许多限制，而且还显著提高了此类设备的功能。使用 UAM 化学设备，通过铜介导的 Huisgen 1,3-偶极环加成反应，成功地合成和优化了一系列具有生物重要性的 1,4-二取代 1,2,3-三唑化合物。通过利用 UAM 和连续流动处理的独特性质，该装置能够在催化进行的反应的同时提供实时反馈，用于反应监测和优化。
