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在养老院的 HIV 感染者中使用抗逆转录病毒疗法。

Use of antiretroviral therapy in nursing home residents with HIV.

机构信息

Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, Rhode Island, USA.

出版信息

J Am Geriatr Soc. 2022 Jun;70(6):1800-1806. doi: 10.1111/jgs.17763. Epub 2022 Mar 25.

Abstract

BACKGROUND

Antiretroviral therapies (ARTs) are essential HIV care. As people living with HIV age and their presence in nursing homes (NHs) increases, it is critical to evaluate the quality of HIV care. We determine the rate of ART use and examine individual- and facility-level characteristics associated with no ART use in a nationally representative long-stay NH residents with HIV.

METHODS

This retrospective cohort study included all long-stay Medicare fee-for-service NH residents (2013-2016) with HIV who had a valid Minimum Data Set assessment. Residents were followed from long-stay qualification until death, Part D disenrollment, transfer from long-term care to another healthcare setting, or December 31, 2016. We identified individual and facility characteristics that were associated with non-use of ART using generalized estimating equation logistic regression.

RESULTS

Exactly 4171 eligible HIV+ residents from 2459 NHs were included in our study. Only 36% (1507 of 4171) received any ART regimen during an average of 11.6 months of observation. Older age, females, white race, receipt of Medicare skilled nursing benefits, and some major cardiometabolic comorbidities and mental health conditions were associated with non-ART use. Rates of non-ART use did not vary significantly by residents' end-of-life status (p = 0.21). Residents in facilities with a higher HIV concentration [adjusted odds ratio (adjOR) 3.42; 95% confidence interval (CI) 2.13-5.48] and an AIDS unit (adjOR 2.51; 95% CI 1.92-3.30) had higher odds of using an ART.

CONCLUSIONS AND IMPLICATIONS

The rate of ART use by HIV+ long-stay NH residents was low. Facilities' experience with HIV played an important role in ART receipt. Interventions to improve rates of ART use in NHs are urgently needed to ensure optimal health outcomes.

摘要

背景

抗逆转录病毒疗法(ART)是 HIV 护理的关键。随着 HIV 感染者年龄的增长以及他们在养老院(NH)中的比例增加,评估 HIV 护理质量至关重要。我们确定了在具有代表性的长期 NH 居民 HIV 患者中,ART 使用率,并研究了与未使用 ART 相关的个体和设施特征。

方法

本回顾性队列研究纳入了所有长期接受医疗保险付费服务的 NH 居民(2013-2016 年),这些居民具有有效的最低数据评估。居民从长期入住资格开始随访,直至死亡、退出 Part D、从长期护理转至另一个医疗保健机构或 2016 年 12 月 31 日。我们使用广义估计方程逻辑回归识别与未使用 ART 相关的个体和设施特征。

结果

我们的研究共纳入了来自 2459 家 NH 的 4171 名符合条件的 HIV+居民。在平均 11.6 个月的观察期内,仅有 36%(4171 名中的 1507 名)接受了任何 ART 方案。年龄较大、女性、白人、接受医疗保险熟练护理福利以及一些主要的心血管代谢合并症和心理健康状况与未使用 ART 相关。非 ART 使用率与居民的临终状态无显著差异(p=0.21)。HIV 浓度较高的机构(调整后的优势比 [adjOR] 3.42;95%置信区间 [CI] 2.13-5.48)和 AIDS 病房(adjOR 2.51;95% CI 1.92-3.30)的居民使用 ART 的几率更高。

结论和意义

长期 NH 居民 HIV+人群中 ART 使用率较低。机构 HIV 经验对接受 ART 治疗具有重要作用。迫切需要在 NH 中采取干预措施以提高 ART 使用率,以确保获得最佳健康结果。

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