Ruiz Sabina, Vázquez Federico, Pellitero Silvia, Puig-Domingo Manel
Department of Endocrinology and Nutrition, Germans Trias i Pujol University Hospital and Research Institute, Badalona, Catalonia, Spain.
Eur J Endocrinol. 2022 Apr 21;186(6):R79-R92. doi: 10.1530/EJE-21-0899.
Obesity, the growing pandemic of the 21st century, is associated with multiple organ dysfunction, either by a direct increase in fatty organ content or by indirect modifications related to general metabolic changes driven by a specific increase in biologic products. The pituitary gland is not protected against such a situation. Different hypothalamic-pituitary axes experience functional modifications initially oriented to an adaptive situation that, with years of obesity, turn to maladaptive dynamics that contribute to perpetuating obesity and specific symptoms of their hormonal nature. This paper reviews the recent knowledge on obesity-related pituitary dysfunction and its pathogenic mechanisms and discusses potential therapeutic actions aimed at contributing to ameliorating the complex treatment of severe cases of obesity.
肥胖，作为21世纪日益蔓延的流行病，与多器官功能障碍相关，其原因要么是脂肪在器官内的直接堆积，要么是生物产物的特定增加所驱动的一般代谢变化导致的间接改变。垂体也未能免受这种情况的影响。不同的下丘脑 - 垂体轴最初会经历功能改变，这些改变旨在适应某种情况，但随着多年肥胖的发展，会转变为适应不良的动态变化，进而导致肥胖持续存在及其特定的激素性质症状。本文综述了肥胖相关垂体功能障碍及其致病机制的最新知识，并讨论了旨在改善严重肥胖病例复杂治疗的潜在治疗措施。
