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特比萘芬治愈东方蝾螈()

SUCCESSFUL TREATMENT OF IN EASTERN HELLBENDERS () WITH TERBINAFINE.

机构信息

The Ohio State University, Columbus, Ohio 43210, USA.

The Wilds, Cumberland, Ohio 43732, USA.

出版信息

J Zoo Wildl Med. 2022 Mar;53(1):228-231. doi: 10.1638/2020-0146.

Abstract

In 2019, two wild-caught adult female eastern hellbenders () received a preshipment examination and were individually swabbed for chytrid testing via quantitative polymerase chain reaction (qPCR). Physical examination was unremarkable. Both females tested positive for () and negative for (). A course of terbinafine hydrochloride 1% in alcohol was administered in a 0.005% treatment bath for 5 min once daily for 5 d. Both animals were individually retested 1, 3, and 4 wk after treatment using qPCR. All post-treatment samples were negative for and . This report represents the first successful treatment with terbinafine hydrochloride 1% in alcohol to eliminate subclinical infection in eastern hellbenders and underlines the importance of preshipment testing for chytrid in all amphibians being transferred to new facilities or released into the wild as a means to minimize risk of disease introduction via subclinically infected individuals.

摘要

2019 年,两只野生成年东部蝾螈 () 接受了发运前检查,并通过定量聚合酶链反应 (qPCR) 分别进行了壶菌检测拭子取样。体检无异常。两只雌蝾螈均 () 检测呈阳性,() 检测呈阴性。使用 0.005%浓度的治疗浴,每日 1 次,每次 5 分钟,连续 5 天,给予 1%盐酸特比萘芬酒精溶液治疗。治疗后 1、3 和 4 周,分别对两只动物进行了 qPCR 复查。所有治疗后样本均 () 检测呈阴性。本报告代表了首例使用 1%盐酸特比萘芬酒精溶液成功治疗东部蝾螈亚临床感染的案例,强调了在将所有两栖动物转移到新设施或放归野外之前进行壶菌发运前检测的重要性,这是通过亚临床感染个体引入疾病风险最小化的一种手段。

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