头颈部鳞状细胞癌和腺样囊性癌肺转移瘤切除术的肿瘤学结果。

Oncological Outcomes after Pulmonary Metastasectomy for Head and Neck Squamous-Cell Carcinoma and Adenoid Cystic Carcinoma.

机构信息

Department of Otorhinolaryngology-Head & Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea,

Department of Otorhinolaryngology-Head and Neck Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.

出版信息

ORL J Otorhinolaryngol Relat Spec. 2022;84(5):387-395. doi: 10.1159/000522111. Epub 2022 Mar 28.

DOI:10.1159/000522111

PMID:35344950

Abstract

INTRODUCTION

Pulmonary metastatic head and neck cancer has a poor prognosis. Pulmonary metastasectomy has been performed but only in carefully selected patients. The aim of this study was to examine the clinical characteristics and oncological follow-up of patients who underwent pulmonary metastasectomy.

METHODS

Data of 54 patients with squamous-cell carcinoma (SCC) or adenoid cystic carcinoma (ACC) who underwent metastasectomy between 2003 and 2019 at two tertiary referral centers were retrospectively reviewed.

RESULTS

The 3-year and 5-year disease-free survival rates after metastasectomy were 49.9% and 39.9% for SCC and 38.9% and 32.4% for ACC, respectively. Univariate analysis revealed that a disease-free interval (DFI) less than 14 months and R1 resection (hazard ratio [HR] [95% confidence interval]: 2.95 [0.77-5.62], 4.64 [0.99-21.65], respectively) were risk factors for recurrence in SCC and that a high T stage (HR: 5.24 [1.22-22.58]) was a risk factor in ACC. In SCC, a DFI less than 14 months and R1 resection (hazard ratio: 6.35 [1.36-29.54], 12.79 [1.53-106.95], respectively) were risk factors in a multivariate analysis.

CONCLUSION

Pulmonary metastasectomy had a fair effect on head and neck SCC and ACC, and the prognosis was better in SCC patients with a DFI greater than 14 months.

摘要

简介

肺部转移性头颈部癌预后较差。已经进行了肺转移切除术，但仅在经过精心选择的患者中进行。本研究旨在检查接受肺转移切除术的患者的临床特征和肿瘤学随访结果。

方法

回顾性分析了 2003 年至 2019 年在两个三级转诊中心接受肺转移切除术的 54 例鳞状细胞癌（SCC）或腺样囊性癌（ACC）患者的数据。

结果

SCC 患者肺转移切除术后 3 年和 5 年无病生存率分别为 49.9%和 39.9%，ACC 患者分别为 38.9%和 32.4%。单因素分析显示，无病间隔（DFI）<14 个月和 R1 切除（风险比[HR] [95%置信区间]：2.95 [0.77-5.62]，4.64 [0.99-21.65]）是 SCC 患者复发的危险因素，而高 T 期（HR：5.24 [1.22-22.58]）是 ACC 的危险因素。在 SCC 中，DFI<14 个月和 R1 切除（风险比：6.35 [1.36-29.54]，12.79 [1.53-106.95]）是多因素分析中的危险因素。