Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Disease in Zabrze, Poland.
Department Of Cardiology And Structural Heart Diseases, 3rd Division Of Cardiology, Medical University Of Silesia, Katowice, Poland.
Anatol J Cardiol. 2022 Mar;26(3):172-179. doi: 10.5152/AnatolJCardiol.2021.83009.
Data concerning the comparison between transcatheter aortic valve implantation and surgical aortic valve replacement in a real-world setting are scarce and in Central and Eastern Europe no such data exist. In this study, we aimed at analyzing retrospectively the characteristics and outcome of patients with aortic stenosis treated either with surgical aortic valve replacement or transcatheter aortic valve implantation between 2006 and 2016 in the Silesian Province, Poland in a representative real-world cohort.
In the Silesian Cardiovascular Database we retrospectively identified 5186 patients who received either transcatheter aortic valve implantation or surgical aortic valve replacement in 1 of 3 tertiary cardiovascular centers. Baseline characteristics, including relevant clinical history, and outcomes were compared before and after propensity-score matching of both groups, with 348 pairs of patients constituting the propensity-matched study cohort. The primary end-point was 24-month all-cause mortality.
Preoperative characteristics of propensity-matched groups were similar. There was no difference between transcatheter aortic valve implantation and surgical aortic valve replacement groups with respect to the death rate at 2 years (19.9% vs. 15.6%; P =.479). In the transcatheter aortic valve implantation group, cardiac resynchronization therapy devices were more frequently implanted after the procedure (3.7% vs. 0.0, P <.001). The groups had similar rates of myocardial infarction, stroke, and re-hospitalization. Hospital stay in the matched groups was shorter after transcatheter aortic valve implantation: 14.1 versus 15.7 days (P <.001).
At 24 months, transcatheter aortic valve implantation patients had similar outcomes as surgical aortic valve replacement except for a higher rate of cardiac resynchronization therapy device implantation and shorter hospital stay.
在真实环境中,关于经导管主动脉瓣植入术(TAVI)与外科主动脉瓣置换术(SAVR)比较的数据很少,在中东欧地区尚无此类数据。本研究旨在分析 2006 年至 2016 年期间波兰西里西亚省(Silesian Province)在代表性真实环境队列中接受 TAVI 或 SAVR 治疗的主动脉瓣狭窄患者的特征和结局。
我们在西里西亚心血管数据库(Silesian Cardiovascular Database)中回顾性地确定了 5186 名患者,他们在 3 家三级心血管中心中的 1 家接受了 TAVI 或 SAVR。比较了两组患者的基线特征,包括相关临床病史和结局,并在进行倾向评分匹配后进行了比较,其中 348 对患者构成了倾向评分匹配的研究队列。主要终点为 24 个月全因死亡率。
倾向评分匹配组的术前特征相似。在 2 年死亡率方面,TAVI 组与 SAVR 组之间无差异(19.9%比 15.6%;P=.479)。TAVI 组在手术后更常植入心脏再同步治疗装置(3.7%比 0.0%;P<.001)。两组的心肌梗死、卒中和再住院率相似。TAVI 组的住院时间更短:14.1 天比 15.7 天(P<.001)。
在 24 个月时,TAVI 患者的结局与 SAVR 相似,但心脏再同步治疗装置的植入率较高,住院时间较短。