Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.
Anticancer Res. 2022 Apr;42(4):2061-2070. doi: 10.21873/anticanres.15687.
BACKGROUND/AIM: Up-regulation of CD109 occurs in malignant tumours, although its role is unknown. Here we aimed to evaluate the significance of CD109 expression in oropharyngeal squamous cell carcinoma (OPSCC).
Immunohistochemical analysis was performed to assess CD109 expression in 169 patients with OPSCC. We assessed the effects of small interfering RNA (siRNA)-mediated inhibition of CD109 expression on the proliferation and invasiveness of the human papillomavirus 16-positive (HPV16) head and neck SCC cell line UM-SCC-47.
Expression of CD109 was associated with higher tumour differentiation in p16 OPSCC (p=0.0036), and the CD109 subgroup experienced significantly shorter progression-free survival (p=0.03). UM-SCC-47 cells with siRNA-mediated inhibition of CD109 expression showed reduced invasiveness (p=0.07).
CD109 expression is associated with poor prognosis of HPV16 OPSCCs.
背景/目的：CD109 在恶性肿瘤中上调，但其作用尚不清楚。本研究旨在评估 CD109 在口咽鳞状细胞癌（OPSCC）中的表达意义。
对 169 例 OPSCC 患者进行免疫组织化学分析，评估 CD109 的表达。采用小干扰 RNA（siRNA）抑制 CD109 表达，评估其对 HPV16 阳性（HPV16+）头颈部 SCC 细胞系 UM-SCC-47 的增殖和侵袭能力的影响。
p16 OPSCC 中 CD109 的表达与肿瘤分化程度较高相关（p=0.0036），CD109 亚组的无进展生存期明显缩短（p=0.03）。CD109 表达受 siRNA 抑制的 UM-SCC-47 细胞侵袭能力降低（p=0.07）。
CD109 的表达与 HPV16+OPSCC 的不良预后相关。
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