Denis F, Adenis J P, Mounier M, Monassier M
Pathol Biol (Paris). 1986 May;34(5):357-9.
The intraocular distribution of fosfomycin was studied in 32 patients undergoing cataract surgery and in 8 rabbits after experimental infection of one eye by Staphylococcus aureus. Concentrations found 1 to 6 hours after termination of a 4 g fosfomycin infusion ranged from 14 to 18.8 mg/l in the aqueous humor and 8 to 12.5 mg/l in the vitreous body. These levels are higher than the MICs for 80 to 90% of the bacteria responsible for endophthalmitis. In each rabbit, the fosfomycin concentration in the infected eye as compared to the healthy eye was increased 2.5 to 5--fold for the aqueous humor and 4.9 to 19.2--fold for the vitreous body. Fosfomycin, in association with a third generation cephalosporin (ceftriaxone) or one of the new quinolones (pefloxacin) can be recommended for the prevention or early treatment of endophthalmitis.
在32例接受白内障手术的患者以及8只经金黄色葡萄球菌单眼实验性感染的兔子中研究了磷霉素的眼内分布情况。在4克磷霉素输注结束后1至6小时测得的房水浓度范围为14至18.8毫克/升，玻璃体浓度为8至12.5毫克/升。这些水平高于80%至90%引起眼内炎的细菌的最低抑菌浓度。在每只兔子中，感染眼与健康眼中磷霉素的浓度相比，房水升高了2.5至5倍，玻璃体升高了4.9至19.2倍。磷霉素与第三代头孢菌素（头孢曲松）或一种新型喹诺酮类药物（培氟沙星）联合使用，可推荐用于预防或早期治疗眼内炎。
