Amtaghri Smail, Amssayef Ayoub, Slaoui Miloudia, Eddouks Mohamed
Department of Biology Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, Errachidia, Morocco. BP 509 Errachidia, Morocco.
Team EMDD, Center of CERNE2D, Ecole Supérieure de Technologie, Boulevard Mohamed VI Salé, Université Mohammed V, Rabat, Morocco.
Cardiovasc Hematol Disord Drug Targets. 2022;22(1):27-37. doi: 10.2174/1871529X22666220329190331.
The aim of the study was to assess the antihypertensive activity of Hibiscus rosasinensis.
Hibiscus rosa-sinensis is used traditionally to treat hypertension.
The goal of the study was to investigate the effect of the aqueous extract of Hibiscus rosa- sinensis flowers (AEHRS) on resting blood pressure in rats.
In the present study, AEHRS was prepared, and its antihypertensive activity was evaluated using in vivo and in vitro studies. In the in vivo study, hypertensive and normotensive rats were treated by AEHRS (100 mg/kg) orally for 6 hours in the acute treatment and for 7 days in the subchronic treatment. Systolic, diastolic, and mean arterial blood pressure values and heart rate were then recorded using a tail-cuff and a computer-assisted monitoring device. To assess the vasorelaxant activity of AEHRS, isolated thoracic aortic rings were suspended in a tissue bath, and changes in tension were recorded using a data acquisition system. Potential pathways involved in the vasorelaxant activity were evaluated using several standard pharmacological agents.
The results indicated that repeated oral administration of AEHRS during 7 days lowered systolic, diastolic, and mean arterial blood pressure in hypertensive rats without affecting normotensive rats. Furthermore, the data revealed that AEHRS exerts vasorelaxant properties via an endothelium- independent pathway. More interestingly, the study demonstrates that the vasorelaxant capacity of AEHRS seems to be exerted through the stimulation of angiotensin-converting enzyme-2 (ACE-2) and the inhibition of Ca channels pathway.
The present study revealed that aqueous extract of Hibiscus rosa-sinensis has a significant antihypertensive activity and that its vasorelaxant effect may be mediated through stimulation of ACE-2, and inhibition of the Ca channels.
本研究旨在评估朱槿的降压活性。
传统上，朱槿用于治疗高血压。
本研究的目的是调查朱槿花水提取物（AEHRS）对大鼠静息血压的影响。
在本研究中，制备了AEHRS，并通过体内和体外研究评估其降压活性。在体内研究中，高血压大鼠和正常血压大鼠在急性治疗中口服AEHRS（100mg/kg）6小时，在亚慢性治疗中口服7天。然后使用尾袖带和计算机辅助监测设备记录收缩压、舒张压、平均动脉血压值和心率。为了评估AEHRS的血管舒张活性，将离体胸主动脉环悬挂在组织浴中，并使用数据采集系统记录张力变化。使用几种标准药理学试剂评估血管舒张活性中涉及的潜在途径。
结果表明，在7天内重复口服AEHRS可降低高血压大鼠的收缩压、舒张压和平均动脉血压，而不影响正常血压大鼠。此外，数据显示AEHRS通过非内皮依赖途径发挥血管舒张特性。更有趣的是，该研究表明AEHRS的血管舒张能力似乎是通过刺激血管紧张素转换酶2（ACE-2）和抑制钙通道途径来实现的。
本研究表明，朱槿水提取物具有显著的降压活性，其血管舒张作用可能是通过刺激ACE-2和抑制钙通道来介导的。
