Dominican Dermatological Institute and Skin Surgery Dr. Huberto Bogaert, Dominican Republic.
Mycology Service, General Hospital Dr. Manuel Gea González, Mexico.
Jpn J Infect Dis. 2022 Jul 22;75(4):427-430. doi: 10.7883/yoken.JJID.2021.709. Epub 2022 Mar 31.
The causative agents of leprosy are Mycobacterium leprae and M. lepromatosis. Mycobacterium lepromatosis was found in 2008 to cause diffuse lepromatous leprosy in Mexican patients. This study aimed to identify M. leprae and M. lepromatosis in paraffin-embedded skin samples from Caribbean patients with leprosy. A total of six skin samples were obtained from the Dominican Republic. All cases presented the multibacillary form; five were nodular lepromatous leprosy, and one was borderline lepromatous leprosy. All patients received multidrug therapy. Molecular identification was achieved using the M. leprae-specific repetitive element for M. leprae and the hemN gene for M. lepromatosis. Mycobacterium leprae was identified in two lepromatous leprosy cases, and one borderline lepromatous leprosy case; M. lepromatosis was found in one nodular lepromatous leprosy case. Both Mycobacterium species were present in two nodular lepromatous leprosy cases. This is the first report of M. lepromatosis in the Dominican Republic.
麻风病的病原体是麻风分枝杆菌和麻风分枝杆菌。2008 年发现麻风分枝杆菌可导致墨西哥患者发生弥漫性麻风。本研究旨在从加勒比麻风病患者的石蜡包埋皮肤样本中鉴定麻风分枝杆菌和麻风分枝杆菌。共从多米尼加共和国获得 6 份皮肤样本。所有病例均表现为多菌型；5 例为结节性麻风，1 例为界限性麻风。所有患者均接受了多药治疗。采用麻风分枝杆菌特异性重复元件鉴定麻风分枝杆菌，采用 hemN 基因鉴定麻风分枝杆菌。在 2 例瘤型麻风病例和 1 例界限性麻风病例中鉴定出麻风分枝杆菌，在 1 例结节性麻风病例中鉴定出麻风分枝杆菌。两种分枝杆菌均存在于 2 例结节性麻风病例中。这是多米尼加共和国首例麻风分枝杆菌的报告。
