Department of Surgery, Yanbian University, Yanji, Jilin, China,Department of Thoracic Surgery Medicine, Affiliated Hospital of Yanbian University, Yanji, Jilin, China.
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000029047.
Fetal lung adenocarcinoma (FLAC) is a rare malignant tumor that occurs in the alveolar epithelium. FLAC, as a distinct entity, is a malignancy with a very low incidence, accounting for less than 0.5% of all lung tumors, with a high rate of misdiagnosis due to its rarity, lack of typical presentation and imaging signs. According to histopathological differences, FLAC is further divided into 2 types: low-grade FLAC and high-grade FLAC. In the article, we report a young woman who was diagnosed with low-grade fetal-type lung adenocarcinoma.
An 18-year-old female patient was admitted due to cough and chest distress.
The final pathological examination confirmed that the lesion was a low-grade fetal lung adenocarcinoma.
The patient underwent thoracoscopic left lower lobectomy and regional lymph node dissection.
The postoperative course was stable, and no recurrence was observed 1 year after operation.
To the best of our knowledge, there are no previous case reports of low-grade fetal-type adenocarcinoma, TP53 gene mutation, and the significance of its mutation is not extensively studies. FLAC, although extremely rare, is considered in the differential diagnosis of lung cancer. In addition, biopsy, histopathology, and specific immunohistochemical staining of larger tissue specimens are helpful for accurate diagnosis of FLAC.
胎儿型肺腺癌（FLAC）是一种罕见的肺上皮恶性肿瘤。FLAC 作为一种独特的实体瘤，其发病率非常低，不到所有肺部肿瘤的 0.5%，由于其罕见性、缺乏典型表现和影像学特征，误诊率很高。根据组织病理学差异，FLAC 进一步分为 2 型：低级别 FLAC 和高级别 FLAC。本文报道了 1 例年轻女性低级别胎儿型肺腺癌患者。
18 岁女性患者因咳嗽和胸闷入院。
最终的病理检查证实病变为低级别胎儿肺腺癌。
患者接受了胸腔镜下左肺下叶切除术和区域淋巴结清扫术。
术后过程稳定，术后 1 年无复发。
据我们所知，此前尚无低级别胎儿型肺腺癌、TP53 基因突变以及其突变意义的报道。FLAC 虽然极其罕见，但在肺癌的鉴别诊断中应予以考虑。此外，活检、组织病理学和更大组织标本的特定免疫组织化学染色有助于准确诊断 FLAC。
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