Department of Pediatrics, Shandong Provincial Maternal and Child Health Care Hospital, Jinan, China.
Department of Pediatrics, Nanjing Jinling Hospital, Nanjing City, China.
Complement Med Res. 2023;30(3):248-257. doi: 10.1159/000524377. Epub 2022 Mar 31.
Traditional Chinese medicine (TCM) is a type of alternative medicine that has been widely utilized in the prevention and treatment of neuropsychiatric diseases such as schizophrenia, ADHD, Alzheimer disease, and Tourette syndrome (TS) in many countries. However, the results regarding TCM's effectiveness and safety in treating TS are conflicting. Therefore, the goal of the present study is to analyze and summarize the available literature related to the efficacy of TCM in the treatment of tic disorders, especially TS.
Relevant articles for the meta-analysis were searched using appropriate keywords from PubMed, MEDLINE, and CENTRAL databases. Event data for TCM for the treatment of TS in the control and intervention arms were determined from the randomized controlled trials, and diagnostic odds ratio (DOR) and risk of bias analysis were performed. Meta-analysis was performed using MedCalc software, and suitable parameters to assess heterogeneity were computed.
Twelve randomized clinical trials with a total of 1,681 TS patients were included as per the inclusion criteria. The patients' clinical symptoms were improved to a greater extent, and the pooled DOR of 1.311 with a 95% confidence interval (CI) value ranging from 0.804 to 2.139 and I2 value of 72.04% were obtained. The pooled relative risk was 1.09, with a 95% CI value ranging from 0.97 to 1.268. The data heterogeneity was assessed, and we achieved a Q value of 33.54, a p value of 0.0004, and I2 value of 67.21% with a 95% CI value of 32.91-82.10. All these values are statistically significant, with p < 0.005, and confirmed the effectiveness of TCM for TS patients.
The present meta-analysis on account of these statistically significant results highly recommends using TCM to treat TS.
传统中医药（TCM）是一种替代医学，已在许多国家广泛应用于预防和治疗精神神经疾病，如精神分裂症、注意缺陷多动障碍、阿尔茨海默病和妥瑞氏综合征（TS）。然而，关于 TCM 治疗 TS 的有效性和安全性的结果存在争议。因此，本研究的目的是分析和总结 TCM 治疗 tic 障碍，特别是 TS 的现有文献。
使用 PubMed、MEDLINE 和 CENTRAL 数据库中的适当关键字搜索用于荟萃分析的相关文章。从随机对照试验中确定 TCM 治疗 TS 的对照和干预臂的事件数据，并进行诊断比值比（DOR）和偏倚风险分析。使用 MedCalc 软件进行荟萃分析，并计算合适的参数来评估异质性。
根据纳入标准，共有 12 项随机临床试验，共纳入 1681 例 TS 患者。患者的临床症状得到了更大程度的改善，合并 DOR 为 1.311，95%置信区间（CI）值为 0.804 至 2.139，I2 值为 72.04%。合并相对风险为 1.09，95%CI 值为 0.97 至 1.268。评估数据异质性，我们得到 Q 值为 33.54，p 值为 0.0004，I2 值为 67.21%，95%CI 值为 32.91-82.10。所有这些值均具有统计学意义，p<0.005，证实了 TCM 对 TS 患者的有效性。
基于这些具有统计学意义的结果，本荟萃分析强烈推荐使用 TCM 治疗 TS。
